Literature DB >> 19492832

Trans-cyclization of phosphatidylinositol catalyzed by phospholipase C from Streptomyces antibioticus.

Chuan Bai1, Li Zhao, Mario Rebecchi, Ming-Daw Tsai, Karol S Bruzik.   

Abstract

Calcium-dependent phosphatidylinositol-specific phospholipase C from Streptomyces antibioticus (saPLC1) catalyzes the cleavage of phosphatidylinositol (PI) by an unusual mechanism involving a 1,6-cyclization with formation of inositol trans-1,6-cyclic phosphate (1,6-IcP), rather then inositol cis-1,2-cyclic phosphate (1,2-IcP). This conclusion has been reached based on the comparison of the released cyclic phosphate intermediate by the H16A mutant of saPLC1 with a genuine 1,6-IcP synthesized by a chemoenzymatic approach.

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Year:  2009        PMID： 19492832      PMCID： PMC2734487          DOI： 10.1021/ja902326u

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  10 in total

Review 1.  Bacterial phosphatidylinositol-specific phospholipase C: structure, function, and interaction with lipids.

Authors:  O H Griffith; M Ryan
Journal:  Biochim Biophys Acta       Date:  1999-11-23

2.  Reactivities of inositol and ribonucleoside phosphodiesters toward P--O bond cleavage.

Authors:  R J Kubiak; K S Bruzik
Journal:  J Am Chem Soc       Date:  2001-02-28       Impact factor: 15.419

3.  A novel calcium-dependent bacterial phosphatidylinositol-specific phospholipase C displaying unprecedented magnitudes of thio effect, inverse thio effect, and stereoselectivity.

Authors:  Li Zhao; Yinghui Liu; Karol S Bruzik; Ming-Daw Tsai
Journal:  J Am Chem Soc       Date:  2003-01-08       Impact factor: 15.419

4.  Sodium-dependent uptake of [3H]scyllo-inositol by Tetrahymena: incorporation into phosphatidylinositol, phosphatidylinositol-linked glycans, and polyphosphoinositols.

Authors:  P E Ryals; M C Kersting
Journal:  Arch Biochem Biophys       Date:  1999-06-15       Impact factor: 4.013

5.  Two distinct phosphatidylinositol-specific phospholipase Cs from Streptomyces antibioticus.

Authors:  Y Iwasaki; Y Tsubouchi; A Ichihashi; H Nakano; T Kobayashi; H Ikezawa; T Yamane
Journal:  Biochim Biophys Acta       Date:  1998-03-06

6.  Involvement of the Arg-Asp-His catalytic triad in enzymatic cleavage of the phosphodiester bond.

Authors:  R J Kubiak; X Yue; R J Hondal; C Mihai; M D Tsai; K S Bruzik
Journal:  Biochemistry       Date:  2001-05-08       Impact factor: 3.162

7.  Elevated brain scyllo-inositol concentrations in patients with Alzheimer's disease.

Authors:  H Randall Griffith; Jan A den Hollander; Chris C Stewart; William T Evanochko; Steven D Buchthal; Lindy E Harrell; Edward Y Zamrini; John C Brockington; Daniel C Marson
Journal:  NMR Biomed       Date:  2007-12       Impact factor: 4.044

8.  Identification of the inositol isomers present in Tetrahymena.

Authors:  Michael C Kersting; Michele Boyette; Joseph H Massey; Phillip E Ryals
Journal:  J Eukaryot Microbiol       Date:  2003 May-Jun       Impact factor: 3.346

9.  Novel Phosphoinositides in Barley Aleurone Cells (Additional Evidence for the Presence of Phosphatidyl-scyllo-Inositol).

Authors:  B. Narasimhan; G. Pliska-Matyshak; R. Kinnard; S. Carstensen; M. A. Ritter; L. Von Weymarn; PPN. Murthy
Journal:  Plant Physiol       Date:  1997-04       Impact factor: 8.340

10.  Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C.

Authors:  D W Heinz; L O Essen; R L Williams
Journal:  J Mol Biol       Date:  1998-01-30       Impact factor: 5.469
  10 in total
  1 in total

1.  Unique catalytic mechanism of phosphatidylinositol-specific phospholipase C from Streptomyces antibioticus.

Authors:  Chuan Bai; Li Zhao; Ming-Daw Tsai; Karol S Bruzik
Journal:  J Am Chem Soc       Date:  2010-02-03       Impact factor: 15.419
  1 in total

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