BACKGROUND: Adipose tissue (AT) is an important source of interleukin-1 receptor antagonist (IL-1Ra). Its expression is markedly increased in obesity. AIMS AND METHODS: To quantify the associations of IL-1Ra with body fat distribution as well as to examine the respective contributions of IL-1Ra and visceral adiposity to the variation in some cardiometabolic risk (CMR) markers. Plasma IL-1Ra levels were measured in a sample of 117 healthy non-diabetic men (age: 44.9+/-10.1 years; body mass index (BMI): 28.8+/-4.5 kg/m(2)). RESULTS: Plasma IL-1Ra levels correlated positively with BMI, waist girth, and visceral and subcutaneous AT (0.39 < or = r<0.48; P < 0.0001). Multiple regression analyses revealed that visceral AT was the best independent predictor of IL-1Ra levels, explaining 22% (P < 0.0001) of its variance. IL-1Ra (P < 0.05) was an independent predictor of several CMR markers including triglyceride and high-density lipoprotein (HDL) cholesterol levels, cholesterol/HDL cholesterol ratio, glucose and insulin concentrations in response to a 75 g oral glucose load, and fasting insulin levels, in addition to the expected contribution of visceral AT (P < 0.05). CONCLUSIONS: These results suggest that elevated IL-1Ra concentrations are influenced to a greater extent by visceral than subcutaneous adiposity and that IL-1Ra is independently related to some features of CMR beyond the known contribution of visceral adiposity.
BACKGROUND: Adipose tissue (AT) is an important source of interleukin-1 receptor antagonist (IL-1Ra). Its expression is markedly increased in obesity. AIMS AND METHODS: To quantify the associations of IL-1Ra with body fat distribution as well as to examine the respective contributions of IL-1Ra and visceral adiposity to the variation in some cardiometabolic risk (CMR) markers. Plasma IL-1Ra levels were measured in a sample of 117 healthy non-diabeticmen (age: 44.9+/-10.1 years; body mass index (BMI): 28.8+/-4.5 kg/m(2)). RESULTS: Plasma IL-1Ra levels correlated positively with BMI, waist girth, and visceral and subcutaneous AT (0.39 < or = r<0.48; P < 0.0001). Multiple regression analyses revealed that visceral AT was the best independent predictor of IL-1Ra levels, explaining 22% (P < 0.0001) of its variance. IL-1Ra (P < 0.05) was an independent predictor of several CMR markers including triglyceride and high-density lipoprotein (HDL) cholesterol levels, cholesterol/HDL cholesterol ratio, glucose and insulin concentrations in response to a 75 g oral glucose load, and fasting insulin levels, in addition to the expected contribution of visceral AT (P < 0.05). CONCLUSIONS: These results suggest that elevated IL-1Ra concentrations are influenced to a greater extent by visceral than subcutaneous adiposity and that IL-1Ra is independently related to some features of CMR beyond the known contribution of visceral adiposity.
Authors: Fasil Tekola Ayele; Ayo Doumatey; Hanxia Huang; Jie Zhou; Bashira Charles; Michael Erdos; Jokotade Adeleye; Williams Balogun; Olufemi Fasanmade; Thomas Johnson; Johnnie Oli; Godfrey Okafor; Albert Amoah; Benjamin A Eghan; Kofi Agyenim-Boateng; Joseph Acheampong; Clement A Adebamowo; Alan Herbert; Norman Gerry; Michael Christman; Guanjie Chen; Daniel Shriner; Adebowale Adeyemo; Charles N Rotimi Journal: Immunogenetics Date: 2011-12-29 Impact factor: 2.846
Authors: Maren Carstensen; Christian Herder; Mika Kivimäki; Markus Jokela; Michael Roden; Martin J Shipley; Daniel R Witte; Eric J Brunner; Adam G Tabák Journal: Diabetes Date: 2010-02-25 Impact factor: 9.461
Authors: Z M Jilkova; M Hensler; D Medrikova; P Janovska; O Horakova; M Rossmeisl; P Flachs; H Sell; J Eckel; J Kopecky Journal: Int J Obes (Lond) Date: 2013-06-12 Impact factor: 5.095
Authors: Hubert Kolb; Kathrin Lückemeyer; Tim Heise; Christian Herder; Nanette C Schloot; Wolfgang Koenig; Lutz Heinemann; Stephan Martin Journal: PLoS One Date: 2013-08-26 Impact factor: 3.240
Authors: Alexander Strom; Hubert Kolb; Stephan Martin; Christian Herder; Marie-Christine Simon; Wolfgang Koenig; Tim Heise; Lutz Heinemann; Michael Roden; Nanette C Schloot Journal: PLoS One Date: 2012-03-20 Impact factor: 3.240