BACKGROUND: Plus disease is abnormal retinal vascular dilation and tortuosity, and it is now the primary indication for laser treatment in retinopathy of prematurity (ROP). ROPtool is a computer program that measures retinal arteriolar tortuosity. Our aim was to assess the accuracy of ROPtool's newly developed measurement of retinal vascular width (dilation). METHODS: ROPtool was used to measure the width of 154 blood vessels in 20 high-quality RetCam images from 20 premature infants. ROPtool's accuracy was determined by comparing results with the mean grades of 2 authors who scored retinal vascular dilation using a 10-point scale. RESULTS: There was very good correlation (r = 0.80) between ROPtool's measurement of retinal vascular dilation and author judgment. Areas under receiver operating characteristics curves for identification of dilation sufficient for plus disease and for pre-plus disease were 0.93 and 0.90, respectively. At an optimal point on the receiver operating characteristics curve, ROPtool's sensitivity for diagnosing dilation sufficient for plus disease was 89% (24/27), and its specificity was 83% (106/127). CONCLUSION: In addition to measuring retinal vascular tortuosity, ROPtool now accurately measures retinal vascular width in high-quality RetCam images. Application of this technology has the potential to remove subjectivity from the assessment of plus disease.
BACKGROUND: Plus disease is abnormal retinal vascular dilation and tortuosity, and it is now the primary indication for laser treatment in retinopathy of prematurity (ROP). ROPtool is a computer program that measures retinal arteriolar tortuosity. Our aim was to assess the accuracy of ROPtool's newly developed measurement of retinal vascular width (dilation). METHODS: ROPtool was used to measure the width of 154 blood vessels in 20 high-quality RetCam images from 20 premature infants. ROPtool's accuracy was determined by comparing results with the mean grades of 2 authors who scored retinal vascular dilation using a 10-point scale. RESULTS: There was very good correlation (r = 0.80) between ROPtool's measurement of retinal vascular dilation and author judgment. Areas under receiver operating characteristics curves for identification of dilation sufficient for plus disease and for pre-plus disease were 0.93 and 0.90, respectively. At an optimal point on the receiver operating characteristics curve, ROPtool's sensitivity for diagnosing dilation sufficient for plus disease was 89% (24/27), and its specificity was 83% (106/127). CONCLUSION: In addition to measuring retinal vascular tortuosity, ROPtool now accurately measures retinal vascular width in high-quality RetCam images. Application of this technology has the potential to remove subjectivity from the assessment of plus disease.
Authors: Samuel K Houston; Charles C Wykoff; Audina M Berrocal; Ditte J Hess; Timothy G Murray Journal: Lasers Med Sci Date: 2011-12-02 Impact factor: 3.161
Authors: Emanuele Trucco; Alfredo Ruggeri; Thomas Karnowski; Luca Giancardo; Edward Chaum; Jean Pierre Hubschman; Bashir Al-Diri; Carol Y Cheung; Damon Wong; Michael Abràmoff; Gilbert Lim; Dinesh Kumar; Philippe Burlina; Neil M Bressler; Herbert F Jelinek; Fabrice Meriaudeau; Gwénolé Quellec; Tom Macgillivray; Bal Dhillon Journal: Invest Ophthalmol Vis Sci Date: 2013-05-01 Impact factor: 4.799
Authors: Leah A Wittenberg; Nina J Jonsson; R V Paul Chan; Michael F Chiang Journal: J Pediatr Ophthalmol Strabismus Date: 2011-03-01 Impact factor: 1.402