Literature DB >> 1949155

The G protein connection: molecular basis of membrane association.

A M Spiegel1, P S Backlund, J E Butrynski, T L Jones, W F Simonds.   

Abstract

Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.

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Year:  1991        PMID： 1949155     DOI： 10.1016/0968-0004(91)90139-m

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  26 in total

1.  Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram.

Authors:  Y Shakur; J G Pryde; M D Houslay
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857

Review 2.  Receptor-receptor interactions as an integrative mechanism in nerve cells.

Authors:  M Zoli; L F Agnati; P B Hedlund; X M Li; S Ferré; K Fuxe
Journal:  Mol Neurobiol       Date:  1993 Fall-Winter       Impact factor: 5.590

3.  Persistent membrane association of activated and depalmitoylated G protein alpha subunits.

Authors:  C Huang; J A Duncan; A G Gilman; S M Mumby
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-19       Impact factor: 11.205

Review 4.  Signal transduction from membrane to nucleus: the special case for neurons.

Authors:  S O Johanson; M F Crouch; I A Hendry
Journal:  Neurochem Res       Date:  1996-07       Impact factor: 3.996

5.  The role of palmitoylation of the guanine nucleotide binding protein G11 alpha in defining interaction with the plasma membrane.

Authors:  J F McCallum; A Wise; M A Grassie; A I Magee; F Guzzi; M Parenti; G Milligan
Journal:  Biochem J       Date:  1995-09-15       Impact factor: 3.857

6.  Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase.

Authors:  G Scotland; M D Houslay
Journal:  Biochem J       Date:  1995-06-01       Impact factor: 3.857

7.  Lipid modifications of G proteins: alpha subunits are palmitoylated.

Authors:  M E Linder; P Middleton; J R Hepler; R Taussig; A G Gilman; S M Mumby
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205

Review 8.  Signals on proteins, intracellular targeting and inborn errors of organellar metabolism.

Authors:  J M Tager; J M Aerts; C van den Bogert; R J Wanders
Journal:  J Inherit Metab Dis       Date:  1994       Impact factor: 4.982

9.  Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum.

Authors:  Y Shakur; M Wilson; L Pooley; M Lobban; S L Griffiths; A M Campbell; J Beattie; C Daly; M D Houslay
Journal:  Biochem J       Date:  1995-03-15       Impact factor: 3.857

10.  Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins.

Authors:  S A Metz; M E Rabaglia; J B Stock; A Kowluru
Journal:  Biochem J       Date:  1993-10-01       Impact factor: 3.857
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