OBJECTIVE: To describe a patient presenting with the rare constellation of synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma. METHODS: We summarize the clinical presentation, diagnostic work-up, surgical management, and pathologic features of our patient and review the pertinent literature. RESULTS: The patient was a 59-year-old man who presented with severe clinical manifestations of long-standing primary hyperparathyroidism, a serum calcium concentration of 14.4 mg/dL, and a parathyroid hormone level of 2,023 pg/mL. He was found to have a 3.4-cm parathyroid carcinoma on the left side and a 3.2-cm papillary carcinoma in the right thyroid lobe. In addition, a 917-mg parathyroid adenoma was found on the right side. CONCLUSION: Synchronous parathyroid and thyroid carcinomas are extremely rare. To our knowledge, our patient is the first documented case with a parathyroid adenoma in addition to synchronous parathyroid and thyroid carcinomas. The presence of concurrent parathyroid carcinoma and parathyroid adenoma can cause diagnostic confusion and should be considered in patients presenting with severe hyperparathyroidism. Any concomitant thyroid nodules must be investigated to rule out thyroid carcinoma.
OBJECTIVE: To describe a patient presenting with the rare constellation of synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma. METHODS: We summarize the clinical presentation, diagnostic work-up, surgical management, and pathologic features of our patient and review the pertinent literature. RESULTS: The patient was a 59-year-old man who presented with severe clinical manifestations of long-standing primary hyperparathyroidism, a serum calcium concentration of 14.4 mg/dL, and a parathyroid hormone level of 2,023 pg/mL. He was found to have a 3.4-cm parathyroid carcinoma on the left side and a 3.2-cm papillary carcinoma in the right thyroid lobe. In addition, a 917-mg parathyroid adenoma was found on the right side. CONCLUSION: Synchronous parathyroid and thyroid carcinomas are extremely rare. To our knowledge, our patient is the first documented case with a parathyroid adenoma in addition to synchronous parathyroid and thyroid carcinomas. The presence of concurrent parathyroid carcinoma and parathyroid adenoma can cause diagnostic confusion and should be considered in patients presenting with severe hyperparathyroidism. Any concomitant thyroid nodules must be investigated to rule out thyroid carcinoma.
Authors: George Schoretsanitis; John Melissas; Maria Kafousi; Nikos Karkavitsas; Dimitris D Tsiftsis Journal: Am J Otolaryngol Date: 2002 Nov-Dec Impact factor: 1.808
Authors: Alexander Stojadinovic; Axel Hoos; Aviram Nissan; Maria E Dudas; Carlos Cordon-Cardo; Ashok R Shaha; Murray F Brennan; Bhuvanesh Singh; Ronald A Ghossein Journal: Hum Pathol Date: 2003-01 Impact factor: 3.466
Authors: Jimmy J Brown; Hezla Mohamed; Lorraine Williams-Smith; Ryan Osborne; Joan Coker; Brian Yee Journal: Ear Nose Throat J Date: 2002-06 Impact factor: 1.697
Authors: Gustavo G Fernandez-Ranvier; Elham Khanafshar; Kristin Jensen; Rasa Zarnegar; James Lee; Electron Kebebew; Quan-Yang Duh; Orlo H Clark Journal: Cancer Date: 2007-07-15 Impact factor: 6.860
Authors: Trisha M Shattuck; Stiina Välimäki; Takao Obara; Randall D Gaz; Orlo H Clark; Dolores Shoback; Margaret E Wierman; Katsuyoshi Tojo; Christiane M Robbins; John D Carpten; Lars-Ove Farnebo; Catharina Larsson; Andrew Arnold Journal: N Engl J Med Date: 2003-10-30 Impact factor: 91.245
Authors: Petr Libánský; Svatopluk Adámek; Petr Broulík; Martina Fialová; Josef Kubinyi; Robert Lischke; Ondřej Naňka; Pavel Pafko; Jiří Šedý; Vladimír Bobek Journal: In Vivo Date: 2017 Sep-Oct Impact factor: 2.155
Authors: Lorenzo Zelano; Pietro Locantore; Carlo Antonio Rota; Caterina Policola; Andrea Corsello; Esther Diana Rossi; Vittoria Rufini; Luca Zagaria; Marco Raffaelli; Alfredo Pontecorvi Journal: Front Endocrinol (Lausanne) Date: 2022-07-07 Impact factor: 6.055