INTRODUCTION: Immunohistochemical studies of paraneoplastic cerebellar degeneration (PCD) are rare, and the findings vary. MATERIALS AND METHODS: We performed morphological and immunohistochemical characterization of the brain, medulla and tumour of two patients with PCD, Yo antibodies and ovarian adenocarcinoma. RESULTS: The cerebellum of both patients had extensive loss of Purkinje cells. Microglia activation and T cells were found in the cerebellum, but B cells or deposits of IgG or complement were not detected. Microglia activation was also present in the brain stem and medulla. T cells were found in the ovarian adenocarcinoma. CONCLUSION: PCD is characterized by loss of Purkinje cells and microglia activation, and the presence of T cells indicates cellular immune reactions in PCD and in ovarian cancer.
INTRODUCTION: Immunohistochemical studies of paraneoplastic cerebellar degeneration (PCD) are rare, and the findings vary. MATERIALS AND METHODS: We performed morphological and immunohistochemical characterization of the brain, medulla and tumour of two patients with PCD, Yo antibodies and ovarian adenocarcinoma. RESULTS: The cerebellum of both patients had extensive loss of Purkinje cells. Microglia activation and T cells were found in the cerebellum, but B cells or deposits of IgG or complement were not detected. Microglia activation was also present in the brain stem and medulla. T cells were found in the ovarian adenocarcinoma. CONCLUSION:PCD is characterized by loss of Purkinje cells and microglia activation, and the presence of T cells indicates cellular immune reactions in PCD and in ovarian cancer.
Authors: Richard M Ransohoff; Dorothy Schafer; Angela Vincent; Nathalie E Blachère; Amit Bar-Or Journal: Neurotherapeutics Date: 2015-10 Impact factor: 7.620
Authors: Tilo W Eichler; Cecilie Totland; Mette Haugen; Tor H Qvale; Kibret Mazengia; Anette Storstein; Bjørn I Haukanes; Christian A Vedeler Journal: PLoS One Date: 2013-06-18 Impact factor: 3.240
Authors: Cecilie Totland; Nina K Aarskog; Tilo W Eichler; Mette Haugen; Jane K Nøstbakken; Sissel E Monstad; Helga B Salvesen; Sverre Mørk; Bjørn I Haukanes; Christian A Vedeler Journal: Cancer Immunol Immunother Date: 2010-11-16 Impact factor: 6.968