[Tissue necrosis following intramuscular administration of various drugs (Nicolau syndrome): clinical presentation, pathophysiology and treatment].

Skin and soft tissue necrosis is a rare but serious complication following intramuscular administration of various drugs (Nicolau syndrome). It typically presents with pain and pallor at the injection site, followed by erythema and livedoid reticular patch that progresses to necrosis. The pathogenesis is not completely understood, although vascular origin (i.e. damage to an end artery at the injection site) seems to be the most realistic hypothesis. This review aims to provide an overview of the currently available Literature.