OBJECTIVE: The aim of the study is to investigate the prevalence of cognitive impairment 100 and frontotemporal dysfunction in Chinese patients with motor neuron disease (MND). METHODS: patients diagnosed as MND underwent a series of survey including mini mental state examination (MMSE), neuropsychiatry inventory (NPI), Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA).Demographics, site of onset, and disease severity-functional rating scale (FRS) were also investigated. RESULTS: The prevalence of mild cognitive impairment determined with MMSE score was 24.2%. Comparison between patients with normal and abnormal MMSE showed statistic differences in depression state and FRS score. Since patients with anxiety and depression would also have abnormal NPI, a follow up study after 3-month antidepressive therapy for the depression patients was made and 2 patients were found to have probably frontotemporal dysfunction lasting for more than 6 months. CONCLUSION: MND patients might have mild impairment of cognitive function and some of the patients were neuroethologically abnormal. 2 of the patients might have frontotemporal dysfunction.
OBJECTIVE: The aim of the study is to investigate the prevalence of cognitive impairment 100 and frontotemporal dysfunction in Chinese patients with motor neuron disease (MND). METHODS:patients diagnosed as MND underwent a series of survey including mini mental state examination (MMSE), neuropsychiatry inventory (NPI), Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA).Demographics, site of onset, and disease severity-functional rating scale (FRS) were also investigated. RESULTS: The prevalence of mild cognitive impairment determined with MMSE score was 24.2%. Comparison between patients with normal and abnormal MMSE showed statistic differences in depression state and FRS score. Since patients with anxiety and depression would also have abnormal NPI, a follow up study after 3-month antidepressive therapy for the depressionpatients was made and 2 patients were found to have probably frontotemporal dysfunction lasting for more than 6 months. CONCLUSION: MND patients might have mild impairment of cognitive function and some of the patients were neuroethologically abnormal. 2 of the patients might have frontotemporal dysfunction.