BACKGROUND: Gray matter (GM) magnetic resonance imaging (MRI) T2 hypointensity, a putative marker of iron deposition, commonly occurs in multiple sclerosis (MS). However, GM T2 hypointensity in benign MS (BMS) has not yet been characterized. OBJECTIVE: To determine the presence of deep GM T2 hypointensity in BMS, compare it to secondary progressive (SP) MS and assess its association with clinical and diffusion tensor (DT) MRI measures. METHODS: Thirty-five cognitively unimpaired BMS, 26 SPMS patients, and 25 healthy controls were analyzed for normalized T2-intensity in the basal ganglia and thalamus, global T2 hyperintense lesion volume, global atrophy, and white matter and GM DT metrics. RESULTS: BMS and SPMS patients showed deep GM T2 hypointensity compared with controls. T2 hypointensity was similar in both MS subgroups and moderately correlated (r = -0.45 to 0.42) with DT MRI metrics. GM T2 hypointensity in BMS showed a weak to moderate correlation (r = -0.44 to -0.35) with disability. CONCLUSIONS: GM in BMS is not spared from structural change including iron deposition. However, while T2 hypointensity is related to global tissue disruption reflected in DT MRI, the expression of benign versus non-benign MS is likely related to other factors.
BACKGROUND: Gray matter (GM) magnetic resonance imaging (MRI) T2 hypointensity, a putative marker of iron deposition, commonly occurs in multiple sclerosis (MS). However, GM T2 hypointensity in benign MS (BMS) has not yet been characterized. OBJECTIVE: To determine the presence of deep GM T2 hypointensity in BMS, compare it to secondary progressive (SP) MS and assess its association with clinical and diffusion tensor (DT) MRI measures. METHODS: Thirty-five cognitively unimpaired BMS, 26 SPMS patients, and 25 healthy controls were analyzed for normalized T2-intensity in the basal ganglia and thalamus, global T2 hyperintense lesion volume, global atrophy, and white matter and GM DT metrics. RESULTS: BMS and SPMS patients showed deep GM T2 hypointensity compared with controls. T2 hypointensity was similar in both MS subgroups and moderately correlated (r = -0.45 to 0.42) with DT MRI metrics. GM T2 hypointensity in BMS showed a weak to moderate correlation (r = -0.44 to -0.35) with disability. CONCLUSIONS: GM in BMS is not spared from structural change including iron deposition. However, while T2 hypointensity is related to global tissue disruption reflected in DT MRI, the expression of benign versus non-benign MS is likely related to other factors.
Authors: Alireza Minagar; Michael H Barnett; Ralph H B Benedict; Daniel Pelletier; Istvan Pirko; Mohamad Ali Sahraian; Elliott Frohman; Robert Zivadinov Journal: Neurology Date: 2013-01-08 Impact factor: 9.910
Authors: J Hagemeier; B Weinstock-Guttman; N Bergsland; M Heininen-Brown; E Carl; C Kennedy; C Magnano; D Hojnacki; M G Dwyer; R Zivadinov Journal: AJNR Am J Neuroradiol Date: 2012-03-29 Impact factor: 3.825
Authors: Julia Pakpoor; Brandon Seminatore; Jennifer S Graves; Teri Schreiner; Amy T Waldman; Timothy E Lotze; Anita Belman; Benjamin M Greenberg; Bianca Weinstock-Guttman; Gregory Aaen; Jan-Mendelt Tillema; Jamie C McDonald; Janace Hart; Jayne M Ness; Yolanda Harris; Jennifer Rubin; Meghan Candee; Lauren Krupp; Mark Gorman; Leslie Benson; Moses Rodriguez; Tanuja Chitnis; Soe Mar; Ilana Kahn; John Rose; Suzan L Carmichael; Shelly Roalstad; Michael Waltz; T Charles Casper; Emmanuelle Waubant Journal: Mult Scler Date: 2017-06-13 Impact factor: 6.312