| Literature DB >> 19482554 |
James M Kelley1, Jeffrey C Edberg, Robert P Kimberly.
Abstract
Wegener's granulomatosis (WG) is an autoimmune condition marked by vasculitis of small and medium sized vessels particularly affecting the upper respiratory tract and kidneys. There is a strong mucosal component similar to other autoimmune conditions such as systemic lupus erythematosus and Behçet's disease. While the pathogenesis of WG is not completely known, auto-antibodies such as IgG ANCAs have been implicated in endovascular damage and modulation of neutrophil/monocyte responses by Fc receptor (FcR) signaling. Due to the substantial mucosal involvement in WG (oral, nasal, and upper respiratory tract involvement), it is probable that IgA antibodies (perhaps IgA ANCAs) play a role in disease. Given discrepancies in associating ANCA levels with disease activity, future work should determine if IgA ANCAs are present in WG patients and examine the biology underlying the ANCAs' signaling partners--the FcRs. Copyright 2009 Elsevier Inc. All rights reserved.Entities:
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Year: 2009 PMID： 19482554 PMCID： PMC2817984 DOI： 10.1016/j.clim.2009.04.014
Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969