Literature DB >> 19482473

Synthesis and antiviral activity of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols) against peste des petits ruminant virus (PPRV).

Kuppusamy Sujatha1, Gnanamani Shanthi, Nagarajan Panneer Selvam, Seeralan Manoharan, Paramasivan T Perumal, Melani Rajendran.   

Abstract

An efficient and eco-friendly method for the synthesis of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols) has been accomplished by tandem Knoevenagel-Michael reaction of two equivalents of 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one with various aromatic aldehydes catalyzed by ceric ammonium nitrate (CAN) in water. All the synthesized compounds 3a-j were evaluated for in vitro antiviral activity against peste des petits ruminant virus (PPRV). Compound 3i emerged as the most interesting compound in this series exhibiting excellent antiviral activity against PPRV and found to be more potent than the standard drug ribavirin used.

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Year:  2009        PMID： 19482473     DOI： 10.1016/j.bmcl.2009.02.113

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

Review 1.  Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.

Authors:  Khalid Karrouchi; Smaail Radi; Youssef Ramli; Jamal Taoufik; Yahia N Mabkhot; Faiz A Al-Aizari; M'hammed Ansar
Journal:  Molecules       Date:  2018-01-12       Impact factor: 4.411

2.  Synthesis and anti-bacterial activities of some novel Schiff bases derived from aminophenazone.

Authors:  Abdullah M Asiri; Salman A Khan
Journal:  Molecules       Date:  2010-10-08       Impact factor: 4.411

3.  Evaluation of the Anti-Leishmania mexicana and -Trypanosoma brucei Activity and Mode of Action of 4,4'-(Arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol).

Authors:  Olalla Barreiro-Costa; Cristina Quiroga Lozano; Erika Muñoz; Patricio Rojas-Silva; Andrea Medeiros; Marcelo A Comini; Jorge Heredia-Moya
Journal:  Biomedicines       Date:  2022-08-07

4.  Meglumine-Promoted Eco-Compatible Pseudo-Three-Component Reaction for the Synthesis of 1,1-Dihomoarylmethane Scaffolds and Their Green Credentials.

Authors:  Manan S Patel; Jaydeepkumar N Parekh; Dipakkumar D Chudasama; Harsh C Patel; Priyanka Dalwadi; Anju Kunjadiya; Vaibhav Bhatt; Kesur R Ram
Journal:  ACS Omega       Date:  2022-08-18

5.  Visible Light-Promoted Green and Sustainable Approach for One-Pot Synthesis of 4,4'-(Arylmethylene)bis(1H-pyrazol-5-ols), In Vitro Anticancer Activity, and Molecular Docking with Covid-19 Mpro.

Authors:  Anamika Gupta; Safia Iqbal; Mohd Kamil Hussain; Mohd Rehan Zaheer; Krapa Shankar
Journal:  ACS Omega       Date:  2022-09-14

6.  Novel 1,2,4-triazole analogues as mushroom tyrosinase inhibitors: synthesis, kinetic mechanism, cytotoxicity and computational studies.

Authors:  Balasaheb D Vanjare; Prasad G Mahajan; Nilam C Dige; Hussain Raza; Mubashir Hassan; Yohan Han; Song Ja Kim; Sung-Yum Seo; Ki Hwan Lee
Journal:  Mol Divers       Date:  2020-05-12       Impact factor: 2.943

7.  3-Oxo-N',2-diphenyl-2,3-di-hydro-1H-pyrazole-4-carbohydrazide.

Authors:  Joel T Mague; Shaaban K Mohamed; Mehmet Akkurt; Eman A Ahmed; Mustafa R Albayati
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-06-25
  7 in total

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