Literature DB >> 19481935

Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents.

Laixing Hu1, Maureen L Kully, David W Boykin, Norman Abood.   

Abstract

A series of bis-benzimidazole diamidine compounds containing different central linkers has been synthesized and evaluated for in vitro antibacterial activities, including drug-resistant bacterial strains. Seven compounds have shown potent antibacterial activities. The anti-MRSA and anti-VRE activities of compound 1h were more potent than that of the lead compound 1a and vancomycin.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19481935     DOI： 10.1016/j.bmcl.2009.05.061

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Understanding the DNA binding of novel non-symmetrical guanidinium/2-aminoimidazolinium derivatives.

Authors:  Padraic S Nagle; Susan J Quinn; John M Kelly; Daniel H O'Donovan; Amir R Khan; Fernando Rodriguez; Binh Nguyen; W David Wilson; Isabel Rozas
Journal:  Org Biomol Chem       Date:  2010-10-15       Impact factor: 3.876

2.  Bis-benzimidazole hits against Naegleria fowleri discovered with new high-throughput screens.

Authors:  Christopher A Rice; Beatrice L Colon; Mehmet Alp; Hakan Göker; David W Boykin; Dennis E Kyle
Journal:  Antimicrob Agents Chemother       Date:  2015-01-20       Impact factor: 5.191

3.  A distal vinyl shift (DVS) through quadruple domino reaction: synthesis of N-vinyl benzoheterocyclic scaffolds.

Authors:  Manickam Bakthadoss; Mohammad Mushaf
Journal:  RSC Adv       Date:  2018-03-28       Impact factor: 4.036

4.  Selective Inhibition of Bacterial Topoisomerase I by alkynyl-bisbenzimidazoles.

Authors:  Nihar Ranjan; Geraldine Fulcrand; Ada King; Joseph Brown; Xiuping Jiang; Fenfei Leng; Dev P Arya
Journal:  Medchemcomm       Date:  2014-06-01       Impact factor: 3.597

5.  Design and synthesis of anti-MRSA benzimidazolylbenzene-sulfonamides. QSAR studies for prediction of antibacterial activity.

Authors:  Marco Martín González-Chávez; Francisco Méndez; Roberto Martínez; Cuaúhtemoc Pérez-González; Fidel Martínez-Gutiérrez
Journal:  Molecules       Date:  2010-12-29       Impact factor: 4.411

6.  Microwave-assisted Cu(I)-catalyzed, three-component synthesis of 2-(4-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-1H-benzo[d]imidazoles.

Authors:  Yogesh Kumar; Vijay Bahadur; Anil Kumar Singh; Virinder Singh Parmar; Erik V Van der Eycken; Brajendra Kumar Singh
Journal:  Beilstein J Org Chem       Date:  2014-06-24       Impact factor: 2.883

7.  Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA.

Authors:  Andrea Bistrović; Luka Krstulović; Ivana Stolić; Domagoj Drenjančević; Jasminka Talapko; Martin C Taylor; John M Kelly; Miroslav Bajić; Silvana Raić-Malić
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.