| Literature DB >> 19481931 |
K Karthikeyan1, T Veenus Seelan, K G Lalitha, P T Perumal.
Abstract
Pyrazolyl isoxazolines and isoxazoles were synthesised in moderate to good yields using 1,3-dipolar cycloaddition of pyrazole derived nitrile oxide with various dipolarophiles such as N-substituted maleimide, diethylacetylene dicarboxylate and phenylacetylene. The synthesized compounds were evaluated for antinociceptive activities. The 3-pyrazolyl-4,5-dicarbethoxy isoxazoles (9a-c) exhibited the maximum antinociceptive activity.Entities:
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Year: 2009 PMID： 19481931 DOI： 10.1016/j.bmcl.2009.05.055
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823