| Literature DB >> 19481908 |
Kalimuthu Kalishwaralal1, Elayappan Banumathi, SureshBabu Ram Kumar Pandian, Venkataraman Deepak, Jeyaraj Muniyandi, Soo Hyun Eom, Sangiliyandi Gurunathan.
Abstract
Angiogenesis, the growth of new blood vessels from pre-existing vasculature is of physiological and pathological importance. We have investigated the anti-angiogenic potential of silver nanoparticles, produced by Bacillus licheniformis. Bovine retinal endothelial cells (BRECs) were treated with the different concentrations of silver nanoparticles for 24 h in the presence and absence of vascular endothelial growth factor (VEGF), where 500 nM (IC50) of silver nanoparticle concentration, was able to block the proliferation and migration of BRECs. The cells showed a clear enhancement in caspase-3 activity and formation of DNA ladders, evidence of induction of apoptosis. Here we report for the first time that silver nanoparticles inhibit cell survival via PI3K/Akt dependent pathway in Bovine retinal endothelial cells.Entities:
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Year: 2009 PMID： 19481908 DOI： 10.1016/j.colsurfb.2009.04.025
Source DB: PubMed Journal: Colloids Surf B Biointerfaces ISSN： 0927-7765 Impact factor: 5.268