| Literature DB >> 19480955 |
Elisabetta Tanzi1, Antonella Amendola, Silvia Bianchi, M Michela Fasolo, Rosangela Beretta, Elena Pariani, Alessandra Zappa, Elena Frati, Giovanna Orlando.
Abstract
A cross-sectional study was carried out to improve the state of evidence regarding the spectrum of HPV types and HPV-16 LCR variants circulating among men and women infected with HIV-1 in Italy. This study, conducted in 518 HIV-positive subjects (346 males and 172 females), showed a high prevalence of HPV anal infections (88.7%) in men and of cervical infections (65.1%) in women. A wide spectrum of HPV genotypes has been observed, as both single and multiple infections. Low-risk HPV types 6, 11 and 61 were frequently detected. HPV-16 was the prevalent high-risk type. Fourteen different HPV-16 LCR variants were found. Ten belonged to the European lineage (78.7% were detected in Italian subjects and 21.3% in foreign-born, all homo/bisexual men), two to the Asiatic lineage and two to the African-2 lineage. This study underlines the great genotypic heterogeneity characterizing anal and cervical HPV infections and the marked polymorphism of the predominant HPV-16 in this high-risk population in Italy.Entities:
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Year: 2009 PMID： 19480955 DOI： 10.1016/j.vaccine.2008.10.091
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641