Literature DB >> 19480551

Pharmacokinetics of 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol and its active metabolite after oral and intravenous administration in rat.

X Zhang1, J Xu, D Zhang, J Gu, Y Zhao.   

Abstract

The pharmacokinetics behaviour of 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol (25-OCH3-PPD) and its active metabolite after oral and intravenous administration in rats were studied. Rats were administered 2.5, 5.0, and 10 mg kg(-1) 25-OCH3-PPD orally after an overnight fasting or by intravenous injection of 5 mg kg(-1) 25-OCH3-PPD via the tail vein. Plasma concentration-time profiles of 25-OCH3-PPD and its active metabolite 25-O-demethylated (25-OH-PPD) in rats were monitored by liquid chromatography-tandem mass spectroscopy (HPLC-MS-MS). The 25-O-demethylated metabolite appears to be a pathway in the phase I metabolism of 25-OCH3-PPD in rats. The plasma concentration of the metabolite was higher than that of the parent compound.

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Year:  2009        PMID： 19480551     DOI： 10.1080/00498250902810951

Source DB:  PubMed          Journal:  Xenobiotica        ISSN： 0049-8254            Impact factor:   1.908


  5 in total

1.  One-pot synthesis, anti-tumor evaluation and structure-activity relationships of novel 25-OCH3-PPD derivatives.

Authors:  Fan-Zhi Qu; Chen Zhao; Jia-Qing Cao; Yan Zhang; Yu-Qing Zhao
Journal:  Medchemcomm       Date:  2017-07-27       Impact factor: 3.597

2.  Self-microemulsifying drug-delivery system for improved oral bioavailability of 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol: preparation and evaluation.

Authors:  Shuang Cai; Cai-Hong Shi; Xiangrong Zhang; Xiaojiao Tang; Hao Suo; Li Yang; Yuqing Zhao
Journal:  Int J Nanomedicine       Date:  2014-02-12

3.  Oral nano-delivery of anticancer ginsenoside 25-OCH3-PPD, a natural inhibitor of the MDM2 oncogene: Nanoparticle preparation, characterization, in vitro and in vivo anti-prostate cancer activity, and mechanisms of action.

Authors:  Sukesh Voruganti; Jiang-Jiang Qin; Sushanta Sarkar; Subhasree Nag; Ismail A Walbi; Shu Wang; Yuqing Zhao; Wei Wang; Ruiwen Zhang
Journal:  Oncotarget       Date:  2015-08-28

4.  Improved oral bioavailability of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol using nanoemulsion based on phospholipid complex: design, characterization, and in vivo pharmacokinetics in rats.

Authors:  Xiangrong Zhang; Yi Zhang; Shuang Guo; Feifei Bai; Tong Wu; Yuqing Zhao
Journal:  Drug Des Devel Ther       Date:  2016-11-10       Impact factor: 4.162

5.  In vitro metabolism of 20(R)-25-methoxyl-dammarane-3, 12, 20-triol from Panax notoginseng in human, monkey, dog, rat, and mouse liver microsomes.

Authors:  Xiangrong Zhang; Ji Zhang; Wei Li; Li Liu; Baoshan Sun; Zhenghong Guo; Caihong Shi; Yuqing Zhao
Journal:  PLoS One       Date:  2014-04-15       Impact factor: 3.240
  5 in total

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