Literature DB >> 1948034

Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA.

S Shimada1, S Kitayama, C L Lin, A Patel, E Nanthakumar, P Gregor, M Kuhar, G Uhl.   

Abstract

A rat dopamine (DA) transporter complementary DNA has been isolated with combined complementary DNA homology and expression approaches. The DA transporter is a 619-amino acid protein with 12 hydrophobic putative membrane-spanning domains and homology to the norepinephrine and gamma-aminobutyric acid transporters. The expressed complementary DNA confers transport of [3H]DA in Xenopus oocytes and in COS cells. Binding of the cocaine analog [3H]CFT ([3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane) to transfected COS cell membranes yields a pharmacological profile similar to that in striatal membranes.

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Year:  1991        PMID： 1948034     DOI： 10.1126/science.1948034

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  77 in total

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3.  Effect of temperature on dopamine transporter function and intracellular accumulation of methamphetamine: implications for methamphetamine-induced dopaminergic neurotoxicity.

Authors:  T Xie; U D McCann; S Kim; J Yuan; G A Ricaurte
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4.  VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity.

Authors:  N Takahashi; L L Miner; I Sora; H Ujike; R S Revay; V Kostic; V Jackson-Lewis; S Przedborski; G R Uhl
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

5.  Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain.

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6.  A Role for p38 Mitogen-activated Protein Kinase-mediated Threonine 30-dependent Norepinephrine Transporter Regulation in Cocaine Sensitization and Conditioned Place Preference.

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7.  Three ubiquitin conjugation sites in the amino terminus of the dopamine transporter mediate protein kinase C-dependent endocytosis of the transporter.

Authors:  Manuel Miranda; Kalen R Dionne; Tatiana Sorkina; Alexander Sorkin
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8.  Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium.

Authors:  K J Buck; S G Amara
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9.  The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter.

Authors:  Ana M Carneiro; Susan L Ingram; Jean-Martin Beaulieu; Ava Sweeney; Susan G Amara; Sheila M Thomas; Marc G Caron; Gonzalo E Torres
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10.  Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo.

Authors:  D F Wong; J C Harris; S Naidu; F Yokoi; S Marenco; R F Dannals; H T Ravert; M Yaster; A Evans; O Rousset; R N Bryan; A Gjedde; M J Kuhar; G R Breese
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-28       Impact factor: 11.205
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