Literature DB >> 19479396

[Asthma therapy: combination of topical glucocorticosteroids and theophylline].

D Ukena1.   

Abstract

In addition to its bronchodilatory effects, theophylline has anti-inflammatory and immunomodulatory effects. Since theophylline and corticosteroids act via different molecular mechanisms, they may be used in combination. Two recently completed trials have demonstrated that with respect to asthma control the combination of inhaled steroid (400 - 800 microg/d) plus theophylline is at least as effective as doubling the dose of inhaled steroid in patients who remain symptomatic on a dosage of 400 - 800 microg daily.

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Year:  1997        PMID： 19479396     DOI： 10.1007/BF03041979

Source DB:  PubMed          Journal:  Med Klin (Munich)        ISSN： 0723-5003


  16 in total

1.  Methylxanthines inhibit exercise-induced bronchoconstriction at low serum theophylline concentration and in a dose-dependent fashion.

Authors:  H Magnussen; G Reuss; R Jörres
Journal:  J Allergy Clin Immunol       Date:  1988-03       Impact factor: 10.793

Review 2.  [Theophylline: new information about a proven drug. The dual effect in therapy of bronchial asthma].

Authors:  D Ukena; A Keller; G W Sybrecht
Journal:  Med Klin (Munich)       Date:  1994-12-15

3.  Bronchial responsiveness to histamine: relationship to diurnal variation of peak flow rate, improvement after bronchodilator, and airway calibre.

Authors:  G Ryan; K M Latimer; J Dolovich; F E Hargreave
Journal:  Thorax       Date:  1982-06       Impact factor: 9.139

4.  Theophylline has a dose-related effect on the airway response to inhaled histamine and methacholine in asthmatics.

Authors:  H Magnussen; G Reuss; R Jörres
Journal:  Am Rev Respir Dis       Date:  1987-11

5.  Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma.

Authors:  D Ukena; U Harnest; R Sakalauskas; P Magyar; N Vetter; H Steffen; S Leichtl; F Rathgeb; A Keller; V W Steinijans
Journal:  Eur Respir J       Date:  1997-12       Impact factor: 16.671

6.  Theophylline: potential antiinflammatory effects in nocturnal asthma.

Authors:  M Kraft; J A Torvik; J B Trudeau; S E Wenzel; R J Martin
Journal:  J Allergy Clin Immunol       Date:  1996-06       Impact factor: 10.793

7.  Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy.

Authors:  J Kidney; M Dominguez; P M Taylor; M Rose; K F Chung; P J Barnes
Journal:  Am J Respir Crit Care Med       Date:  1995-06       Impact factor: 21.405

8.  Efficacy of Uniphyl, salbutamol, and their combination in asthmatic patients on high-dose inhaled steroids.

Authors:  R N Rivington; L P Boulet; J Côté; H Kreisman; D I Small; M Alexander; A Day; Z Harsanyi; A C Darke
Journal:  Am J Respir Crit Care Med       Date:  1995-02       Impact factor: 21.405

9.  Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids.

Authors:  A Woolcock; B Lundback; N Ringdal; L A Jacques
Journal:  Am J Respir Crit Care Med       Date:  1996-05       Impact factor: 21.405

10.  Anti-inflammatory effects of low-dose oral theophylline in atopic asthma.

Authors:  P Sullivan; S Bekir; Z Jaffar; C Page; P Jeffery; J Costello
Journal:  Lancet       Date:  1994-04-23       Impact factor: 79.321
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