Literature DB >> 19478142

Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats.

Hector Vargas-Perez1, Ryan Ting-A Kee, Christine H Walton, D Micah Hansen, Rozita Razavi, Laura Clarke, Mary Rose Bufalino, David W Allison, Scott C Steffensen, Derek van der Kooy.   

Abstract

The neural mechanisms underlying the transition from a drug-nondependent to a drug-dependent state remain elusive. Chronic exposure to drugs has been shown to increase brain-derived neurotrophic factor (BDNF) levels in ventral tegmental area (VTA) neurons. BDNF infusions into the VTA potentiate several behavioral effects of drugs, including psychomotor sensitization and cue-induced drug seeking. We found that a single infusion of BDNF into the VTA promotes a shift from a dopamine-independent to a dopamine-dependent opiate reward system, identical to that seen when an opiate-naïve rat becomes dependent and withdrawn. This shift involves a switch in the gamma-aminobutyric acid type A (GABAA) receptors of VTA GABAergic neurons, from inhibitory to excitatory signaling.

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Year:  2009        PMID： 19478142      PMCID： PMC2913611          DOI： 10.1126/science.1168501

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  20 in total

1.  GABA(A) receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non-dopaminergic neural motivational systems.

Authors:  S R Laviolette; D van der Kooy
Journal:  Eur J Neurosci       Date:  2001-03       Impact factor: 3.386

2.  Responses of ventral tegmental area GABA neurons to brain stimulation reward.

Authors:  S C Steffensen; R S Lee; S H Stobbs; S J Henriksen
Journal:  Brain Res       Date:  2001-07-06       Impact factor: 3.252

3.  Excitotoxic lesions of the tegmental pedunculopontine nucleus impair copulation in naive male rats and block the rewarding effects of copulation in experienced male rats.

Authors:  Tod E Kippin; Derek van der Kooy
Journal:  Eur J Neurosci       Date:  2003-11       Impact factor: 3.386

Review 4.  Neurotrophic mechanisms in drug addiction.

Authors:  Carlos A Bolaños; Eric J Nestler
Journal:  Neuromolecular Med       Date:  2004       Impact factor: 3.843

5.  GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate state.

Authors:  Steven R Laviolette; Derek van der Kooy
Journal:  Eur J Neurosci       Date:  2004-10       Impact factor: 3.386

6.  Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving.

Authors:  Jeffrey W Grimm; Lin Lu; Teruo Hayashi; Bruce T Hope; Tsung-Ping Su; Yavin Shaham
Journal:  J Neurosci       Date:  2003-02-01       Impact factor: 6.167

7.  A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal.

Authors:  Lin Lu; Jack Dempsey; Shirley Y Liu; Jennifer M Bossert; Yavin Shaham
Journal:  J Neurosci       Date:  2004-02-18       Impact factor: 6.167

8.  Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area.

Authors:  Steven R Laviolette; Roger A Gallegos; Steven J Henriksen; Derek van der Kooy
Journal:  Nat Neurosci       Date:  2004-01-18       Impact factor: 24.884

9.  Implication of brain-derived neurotrophic factor in the release of dopamine and dopamine-related behaviors induced by methamphetamine.

Authors:  M Narita; K Aoki; M Takagi; Y Yajima; T Suzuki
Journal:  Neuroscience       Date:  2003       Impact factor: 3.590

10.  BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion.

Authors:  Claudio Rivera; Hong Li; Judith Thomas-Crusells; Hannele Lahtinen; Tero Viitanen; Avtandil Nanobashvili; Zaal Kokaia; Matti S Airaksinen; Juha Voipio; Kai Kaila; Mart Saarma
Journal:  J Cell Biol       Date:  2002-12-09       Impact factor: 10.539
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  69 in total

1.  Morphine Withdrawal Increases Brain-Derived Neurotrophic Factor Precursor.

Authors:  Alessia Bachis; Lee A Campbell; Kierra Jenkins; Erin Wenzel; Italo Mocchetti
Journal:  Neurotox Res       Date:  2017-08-03       Impact factor: 3.911

2.  Elevation of BDNF exon I-specific transcripts in the frontal cortex and midbrain of rat during spontaneous morphine withdrawal is accompanied by enhanced pCreb1 occupancy at the corresponding promoter.

Authors:  Danil I Peregud; Leonid F Panchenko; Natalia V Gulyaeva
Journal:  Neurochem Res       Date:  2014-11-13       Impact factor: 3.996

3.  Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal.

Authors:  Taryn E Grieder; Olivier George; Huibing Tan; Susan R George; Bernard Le Foll; Steven R Laviolette; Derek van der Kooy
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-20       Impact factor: 11.205

4.  Ethanol and nicotine interaction within the posterior ventral tegmental area in male and female alcohol-preferring rats: evidence of synergy and differential gene activation in the nucleus accumbens shell.

Authors:  William A Truitt; Sheketha R Hauser; Gerald A Deehan; Jamie E Toalston; Jessica A Wilden; Richard L Bell; William J McBride; Zachary A Rodd
Journal:  Psychopharmacology (Berl)       Date:  2014-08-26       Impact factor: 4.530

5.  Decoding BDNF-LTP coupling in cocaine addiction.

Authors:  Li-Min Mao; Eugene E Fibuch; John Q Wang
Journal:  Neuron       Date:  2010-09-09       Impact factor: 17.173

Review 6.  GABAA receptor-mediated tonic depolarization in developing neural circuits.

Authors:  Juu-Chin Lu; Yu-Tien Hsiao; Chung-Wei Chiang; Chih-Tien Wang
Journal:  Mol Neurobiol       Date:  2013-09-11       Impact factor: 5.590

7.  Microglia disrupt mesolimbic reward circuitry in chronic pain.

Authors:  Anna M W Taylor; Annie Castonguay; Alison J Taylor; Niall P Murphy; Atefeh Ghogha; Christopher Cook; Lihua Xue; Mary C Olmstead; Yves De Koninck; Christopher J Evans; Catherine M Cahill
Journal:  J Neurosci       Date:  2015-06-03       Impact factor: 6.167

Review 8.  Opioid-induced rewards, locomotion, and dopamine activation: A proposed model for control by mesopontine and rostromedial tegmental neurons.

Authors:  Stephan Steidl; David I Wasserman; Charles D Blaha; John S Yeomans
Journal:  Neurosci Biobehav Rev       Date:  2017-09-23       Impact factor: 8.989

9.  BDNF Val66Met polymorphism tunes frontolimbic circuitry during affective contextual learning.

Authors:  Mbemba Jabbi; Brett Cropp; Tiffany Nash; Philip Kohn; J Shane Kippenhan; Joseph C Masdeu; Raghav Mattay; Bhaskar Kolachana; Karen F Berman
Journal:  Neuroimage       Date:  2017-09-01       Impact factor: 6.556

10.  Dopamine D1 receptors are not critical for opiate reward but can mediate opiate memory retrieval in a state-dependent manner.

Authors:  Ryan Ting-A-Kee; Laura E Mercuriano; Hector Vargas-Perez; Susan R George; Derek van der Kooy
Journal:  Behav Brain Res       Date:  2013-03-26       Impact factor: 3.332
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