Literature DB >> 19477128

Fast and easy access to efficient bifunctional chelators for MRI applications.

Giuseppe Gugliotta1, Mauro Botta, Giovanni Battista Giovenzana, Lorenzo Tei.   

Abstract

Novel bifunctional agents based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) structure with hydroxyl, carboxyl and chloro functional groups were prepared. The Gd(III) complexes show optimal magnetic properties making them very good candidates for conjugation to biomolecules for molecular imaging applications. An example of conjugation to a bile acid derivative is also reported.

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Year:  2009        PMID： 19477128     DOI： 10.1016/j.bmcl.2009.05.024

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Strategies for the preparation of bifunctional gadolinium(III) chelators.

Authors:  Luca Frullano; Peter Caravan
Journal:  Curr Org Synth       Date:  2011-08-01       Impact factor: 1.975

Review 2.  Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Authors:  Jessica Wahsner; Eric M Gale; Aurora Rodríguez-Rodríguez; Peter Caravan
Journal:  Chem Rev       Date:  2018-10-16       Impact factor: 60.622

3.  A new ditopic Gd(III) complex functionalized with an adamantyl moiety as a versatile building block for the preparation of supramolecular assemblies.

Authors:  Giuseppe Gambino; Sara De Pinto; Lorenzo Tei; Claudio Cassino; Francesca Arena; Eliana Gianolio; Mauro Botta
Journal:  J Biol Inorg Chem       Date:  2013-10-08       Impact factor: 3.358

4.  B25716/1: a novel albumin-binding Gd-AAZTA MRI contrast agent with improved properties in tumor imaging.

Authors:  E Gianolio; C Cabella; S Colombo Serra; G Valbusa; F Arena; A Maiocchi; L Miragoli; F Tedoldi; F Uggeri; M Visigalli; P Bardini; S Aime
Journal:  J Biol Inorg Chem       Date:  2014-02-08       Impact factor: 3.358

5.  Synthesis, radiolabeling, and pre-clinical evaluation of [44Sc]Sc-AAZTA conjugate PSMA inhibitor, a new tracer for high-efficiency imaging of prostate cancer.

Authors:  S Ghiani; I Hawala; D Szikra; G Trencsényi; Z Baranyai; G Nagy; A Vágner; R Stefania; S Pandey; A Maiocchi
Journal:  Eur J Nucl Med Mol Imaging       Date:  2021-01-09       Impact factor: 9.236

Review 6.  AAZTA-Derived Chelators for the Design of Innovative Radiopharmaceuticals with Theranostic Applications.

Authors:  Cyril Fersing; Nicolas Masurier; Léa Rubira; Emmanuel Deshayes; Vincent Lisowski
Journal:  Pharmaceuticals (Basel)       Date:  2022-02-16
  6 in total

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