BACKGROUND: With regards to dyshidrosis in Parkinson's disease (PD), there is no established and consistent view on the occurrence sites, frequency and etiology, although there have been several reports on hypohidrosis of the limbs and sudoresis on the face/cervical region. METHODS: Hydrosis in the forearms of PD patients and healthy individuals were compared by quantitative sudomotor axon reflex test (QSART). The expression of various neuropeptides and alpha-synuclein was examined with immunohistochemical staining. RESULTS: There was a significant reduction in QSART of PD patients but not of healthy controls. Reduced expression of vasoactive intestinal polypeptide (VIP) was also detected in the sweat glands of PD patients. CONCLUSION: Reduction in QSART and VIP expression in the sweat glands might be involved in the dyshidrosis of PD patients.
BACKGROUND: With regards to dyshidrosis in Parkinson's disease (PD), there is no established and consistent view on the occurrence sites, frequency and etiology, although there have been several reports on hypohidrosis of the limbs and sudoresis on the face/cervical region. METHODS: Hydrosis in the forearms of PDpatients and healthy individuals were compared by quantitative sudomotor axon reflex test (QSART). The expression of various neuropeptides and alpha-synuclein was examined with immunohistochemical staining. RESULTS: There was a significant reduction in QSART of PDpatients but not of healthy controls. Reduced expression of vasoactive intestinal polypeptide (VIP) was also detected in the sweat glands of PDpatients. CONCLUSION: Reduction in QSART and VIP expression in the sweat glands might be involved in the dyshidrosis of PDpatients.
Authors: Timo Siepmann; Alexandra Pintér; Sylvia J Buchmann; Leonie Stibal; Martin Arndt; Anne Sophie Kubasch; Marie Luise Kubasch; Ana Isabel Penzlin; Elka Frenz; Wagner Zago; Tamás Horváth; Szabolcs Szatmári; Dániel Bereczki; Annamária Takáts; Tjalf Ziemssen; Axel Lipp; Roy Freeman; Heinz Reichmann; Kristian Barlinn; Ben Min-Woo Illigens Journal: Front Neurol Date: 2017-05-26 Impact factor: 4.003
Authors: Heidrun H Krämer; Gothje Lautenschläger; Michael de Azevedo; Kathrin Doppler; Anne Schänzer; Christoph Best; Wolfgang H Oertel; Iris Reuter; Claudia Sommer; Frank Birklein Journal: Brain Behav Date: 2019-11-05 Impact factor: 2.708