Literature DB >> 19476432

Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence.

Odile B Harrison1, Nicholas J Evans, Jessica M Blair, Holly S Grimes, Colin R Tinsley, Xavier Nassif, Paula Kriz, Roisin Ure, Steve J Gray, Jeremy P Derrick, Martin C J Maiden, Ian M Feavers.   

Abstract

The distribution of the hemoglobin receptor gene (hmbR) was investigated among disease and carriage Neisseria meningitidis isolates, revealing that the gene was detected at a significantly higher frequency among disease isolates than among carriage isolates. In isolates without hmbR, the locus was occupied by the cassettes exl2 or exl3 or by a "pseudo hmbR" gene, designated exl4. The hmbR locus exhibited characteristics of a pathogenicity island in published genomes of N. meningitidis, Neisseria gonorrhoeae, and Neisseria lactamica sequence type-640. These data are consistent with a role for the hmbR gene in meningococcal disease.

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Year:  2009        PMID： 19476432      PMCID： PMC2731217          DOI： 10.1086/599377

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  17 in total

1.  HmbR, a hemoglobin-binding outer membrane protein of Neisseria meningitidis, undergoes phase variation.

Authors:  A R Richardson; I Stojiljkovic
Journal:  J Bacteriol       Date:  1999-04       Impact factor: 3.490

2.  Distribution of serogroups and genotypes among disease-associated and carried isolates of Neisseria meningitidis from the Czech Republic, Greece, and Norway.

Authors:  Siamak P Yazdankhah; Paula Kriz; Georgina Tzanakaki; Jenny Kremastinou; Jitka Kalmusova; Martin Musilek; Torill Alvestad; Keith A Jolley; Daniel J Wilson; Noel D McCarthy; Dominique A Caugant; Martin C J Maiden
Journal:  J Clin Microbiol       Date:  2004-11       Impact factor: 5.948

Review 3.  Pathogenicity islands: a molecular toolbox for bacterial virulence.

Authors:  Ohad Gal-Mor; B Brett Finlay
Journal:  Cell Microbiol       Date:  2006-08-24       Impact factor: 3.715

4.  Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms.

Authors:  M C Maiden; J A Bygraves; E Feil; G Morelli; J E Russell; R Urwin; Q Zhang; J Zhou; K Zurth; D A Caugant; I M Feavers; M Achtman; B G Spratt
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-17       Impact factor: 11.205

5.  Comparative genomics identifies the genetic islands that distinguish Neisseria meningitidis, the agent of cerebrospinal meningitis, from other Neisseria species.

Authors:  Agnès Perrin; Stéphane Bonacorsi; Etienne Carbonnelle; Driss Talibi; Philippe Dessen; Xavier Nassif; Colin Tinsley
Journal:  Infect Immun       Date:  2002-12       Impact factor: 3.441

Review 6.  Pathogenicity islands and the evolution of microbes.

Authors:  J Hacker; J B Kaper
Journal:  Annu Rev Microbiol       Date:  2000       Impact factor: 15.500

7.  New Zealand's epidemic of meningococcal disease described using molecular analysis: implications for vaccine delivery.

Authors:  K Dyet; A Devoy; R McDowell; D Martin
Journal:  Vaccine       Date:  2005-03-18       Impact factor: 3.641

8.  Characterization of ST-4821 complex, a unique Neisseria meningitidis clone.

Authors:  Junping Peng; Li Yang; Fan Yang; Jian Yang; Yongliang Yan; Huan Nie; Xiaobing Zhang; Zhaohui Xiong; Yan Jiang; Fan Cheng; Xingye Xu; Shuxia Chen; Lilian Sun; Weijun Li; Yan Shen; Zhujun Shao; Xiaofeng Liang; Jianguo Xu; Qi Jin
Journal:  Genomics       Date:  2007-11-26       Impact factor: 5.736

9.  The Neisseria meningitidis haemoglobin receptor: its role in iron utilization and virulence.

Authors:  I Stojiljkovic; V Hwa; L de Saint Martin; P O'Gaora; X Nassif; F Heffron; M So
Journal:  Mol Microbiol       Date:  1995-02       Impact factor: 3.501

10.  A chromosomally integrated bacteriophage in invasive meningococci.

Authors:  Emmanuelle Bille; Jean-Ralph Zahar; Agnes Perrin; Sandrine Morelle; Paula Kriz; Keith A Jolley; Martin C J Maiden; Catherine Dervin; Xavier Nassif; Colin R Tinsley
Journal:  J Exp Med       Date:  2005-06-20       Impact factor: 14.307
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  23 in total

Review 1.  A journey into the brain: insight into how bacterial pathogens cross blood-brain barriers.

Authors:  Mathieu Coureuil; Hervé Lécuyer; Sandrine Bourdoulous; Xavier Nassif
Journal:  Nat Rev Microbiol       Date:  2017-01-16       Impact factor: 60.633

Review 2.  Evolutionary and genomic insights into meningococcal biology.

Authors:  Holly B Bratcher; Julia S Bennett; Martin C J Maiden
Journal:  Future Microbiol       Date:  2012-07       Impact factor: 3.165

Review 3.  Heme Synthesis and Acquisition in Bacterial Pathogens.

Authors:  Jacob E Choby; Eric P Skaar
Journal:  J Mol Biol       Date:  2016-03-24       Impact factor: 5.469

4.  Comparative genome biology of a serogroup B carriage and disease strain supports a polygenic nature of meningococcal virulence.

Authors:  Biju Joseph; Susanne Schneiker-Bekel; Anja Schramm-Glück; Jochen Blom; Heike Claus; Burkhard Linke; Roland F Schwarz; Anke Becker; Alexander Goesmann; Matthias Frosch; Christoph Schoen
Journal:  J Bacteriol       Date:  2010-08-13       Impact factor: 3.490

5.  Regulatory role of the MisR/S two-component system in hemoglobin utilization in Neisseria meningitidis.

Authors:  Shuming Zhao; Grisselle E Montanez; Pradeep Kumar; Soma Sannigrahi; Yih-Ling Tzeng
Journal:  Infect Immun       Date:  2009-12-14       Impact factor: 3.441

6.  The influence of IS1301 in the capsule biosynthesis locus on meningococcal carriage and disease.

Authors:  Elisabeth Kugelberg; Bridget Gollan; Christopher Farrance; Holly Bratcher; Jay Lucidarme; Ana Belén Ibarz-Pavón; Martin C J Maiden; Ray Borrow; Christoph M Tang
Journal:  PLoS One       Date:  2010-02-25       Impact factor: 3.240

7.  An analysis of the sequence variability of meningococcal fHbp, NadA and NHBA over a 50-year period in the Netherlands.

Authors:  Stefania Bambini; Jurgen Piet; Alessandro Muzzi; Wendy Keijzers; Sara Comandi; Lisa De Tora; Mariagrazia Pizza; Rino Rappuoli; Diederik van de Beek; Arie van der Ende; Maurizio Comanducci
Journal:  PLoS One       Date:  2013-05-24       Impact factor: 3.240

8.  Spectroscopic evidence for a 5-coordinate oxygenic ligated high spin ferric heme moiety in the Neisseria meningitidis hemoglobin binding receptor.

Authors:  David Z Mokry; Angela Nadia-Albete; Michael K Johnson; Gudrun S Lukat-Rodgers; Kenton R Rodgers; William N Lanzilotta
Journal:  Biochim Biophys Acta       Date:  2014-06-23

9.  Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence.

Authors:  Isfahan Tauseef; Odile B Harrison; Karl G Wooldridge; Ian M Feavers; Keith R Neal; Stephen J Gray; Paula Kriz; David P J Turner; Dlawer A A Ala'Aldeen; Martin C J Maiden; Christopher D Bayliss; J G Shaw
Journal:  Microbiology (Reading)       Date:  2011-02-10       Impact factor: 2.777

10.  Genealogical typing of Neisseria meningitidis.

Authors:  Xavier Didelot; Rachel Urwin; Martin C J Maiden; Daniel Falush
Journal:  Microbiology (Reading)       Date:  2009-07-30       Impact factor: 2.777
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