BACKGROUND: Nasal polyposis is highly prevalent in the general population. Its exact origin is unknown, although several factors are involved in the etiology and development of this condition. Clinical patterns, a history of atopy, environmental exposure, eosinophil-mediated inflammation, the presence of inflammatory mediators, and sensitization to some allergens indicate that nasal polyposis is associated with allergic phenomena. The aim of this study was to identify the association between nasal polyposis and allergic factors by examining hypersensitivity reactions to common allergens and environmental exposure that could lead to the development of atopy. METHODS: We conducted a comparative study of 190 patients with nasal polyposis and 190 healthy individuals. The study included clinical and epidemiological variables, environmental exposure factors, and an allergology workup using skin prick tests with 18 inhaled allergens. RESULTS: A total of 121 patients (63.7%) of the 190 were male; 62.1% had a family history of allergy. The incidence of asthma was 48.9% among the patients and only 2.3% among the controls (P < .001). The factor most frequently involved in the patients' symptoms was weather changes (67.4%). Skin prick tests were positive in 63.2% of the patients and 31.1% of the controls. The allergens that most frequently elicited a reaction from the patients in the prick tests were Dermatophagoides pteronyssinus (27.7%), Dermatophagoides farinae (21.3%), and Olea europaea (21.1%). The difference between these results and those of the controls was statistically significant. CONCLUSIONS: Patients with nasal polyposis are sensitive to the most common allergens in our environment and exhibit a clear-cut correlation with other allergic factors, as confirmed by personal and family histories, the presence of chronic rhinitis, and the results of in vivo tests.
BACKGROUND:Nasal polyposis is highly prevalent in the general population. Its exact origin is unknown, although several factors are involved in the etiology and development of this condition. Clinical patterns, a history of atopy, environmental exposure, eosinophil-mediated inflammation, the presence of inflammatory mediators, and sensitization to some allergens indicate that nasal polyposis is associated with allergic phenomena. The aim of this study was to identify the association between nasal polyposis and allergic factors by examining hypersensitivity reactions to common allergens and environmental exposure that could lead to the development of atopy. METHODS: We conducted a comparative study of 190 patients with nasal polyposis and 190 healthy individuals. The study included clinical and epidemiological variables, environmental exposure factors, and an allergology workup using skin prick tests with 18 inhaled allergens. RESULTS: A total of 121 patients (63.7%) of the 190 were male; 62.1% had a family history of allergy. The incidence of asthma was 48.9% among the patients and only 2.3% among the controls (P < .001). The factor most frequently involved in the patients' symptoms was weather changes (67.4%). Skin prick tests were positive in 63.2% of the patients and 31.1% of the controls. The allergens that most frequently elicited a reaction from the patients in the prick tests were Dermatophagoides pteronyssinus (27.7%), Dermatophagoides farinae (21.3%), and Olea europaea (21.1%). The difference between these results and those of the controls was statistically significant. CONCLUSIONS:Patients with nasal polyposis are sensitive to the most common allergens in our environment and exhibit a clear-cut correlation with other allergic factors, as confirmed by personal and family histories, the presence of chronic rhinitis, and the results of in vivo tests.
Authors: Bruce K Tan; Whitney Zirkle; Rakesh K Chandra; David Lin; David B Conley; Anju T Peters; Leslie C Grammer; Robert P Schleimer; Robert C Kern Journal: Int Forum Allergy Rhinol Date: 2011 Mar-Apr Impact factor: 3.858
Authors: Samuel N Helman; Emily Barrow; Thomas Edwards; John M DelGaudio; Joshua M Levy; Sarah K Wise Journal: Immunol Allergy Clin North Am Date: 2020-01-14 Impact factor: 3.479
Authors: Bruce K Tan; Rakesh K Chandra; Jonathan Pollak; Atsushi Kato; David B Conley; Anju T Peters; Leslie C Grammer; Pedro C Avila; Robert C Kern; Walter F Stewart; Robert P Schleimer; Brian S Schwartz Journal: J Allergy Clin Immunol Date: 2013-03-28 Impact factor: 10.793
Authors: Ignacio Dávila; Carmen Rondón; Ana Navarro; Encarnación Antón; Carlos Colás; María Teresa Dordal; María Dolores Ibáñez; Beatriz Fernández-Parra; Magdalena Lluch-Bernal; Víctor Matheu; Javier Montoro; María Cesárea Sánchez; Antonio Valero Journal: Am J Rhinol Allergy Date: 2012 Sep-Oct Impact factor: 2.467