BACKGROUND: A retrospective nationwide study of cancer of the nasal vestibule was conducted to evaluate classification systems and prognostic factors for treatment outcome. METHODS: Patients treated between 1993 and 2002 at head and neck oncology centers in Denmark were included. RESULTS: The 5-year results were locoregional control 67%, overall survival 50%, cancer-specific survival 74%. Cancer-specific survival according to Wang classification was 83%, 63%, and 39% for T1, T2, T3, respectively (p < .000). Regarding T1 tumors, 5-year locoregional control for surgery, surgery + radiotherapy (RT), or RT was 94%, 87%, or 61%, respectively (p < .000). Fifty-four Gray in 18 fractions was found comparable with 66 Gy in 33 fractions regarding T1 tumors. CONCLUSION: This national survey is the largest series of nasal vestibule cancer ever published. Wang classification is more prognostic and easier to use than the Union Internationale Contre le Cancer 2002. Surgery or hypofractionated RT can be used for T1 lesions, whereas larger lesions should be treated with combined approach.
BACKGROUND: A retrospective nationwide study of cancer of the nasal vestibule was conducted to evaluate classification systems and prognostic factors for treatment outcome. METHODS:Patients treated between 1993 and 2002 at head and neck oncology centers in Denmark were included. RESULTS: The 5-year results were locoregional control 67%, overall survival 50%, cancer-specific survival 74%. Cancer-specific survival according to Wang classification was 83%, 63%, and 39% for T1, T2, T3, respectively (p < .000). Regarding T1 tumors, 5-year locoregional control for surgery, surgery + radiotherapy (RT), or RT was 94%, 87%, or 61%, respectively (p < .000). Fifty-four Gray in 18 fractions was found comparable with 66 Gy in 33 fractions regarding T1 tumors. CONCLUSION: This national survey is the largest series of nasal vestibule cancer ever published. Wang classification is more prognostic and easier to use than the Union Internationale Contre le Cancer 2002. Surgery or hypofractionated RT can be used for T1 lesions, whereas larger lesions should be treated with combined approach.
Authors: Justin Wray; Christopher G Morris; Jessica M Kirwan; Robert J Amdur; John W Werning; Peter T Dziegielewski; William M Mendenhall Journal: Eur Arch Otorhinolaryngol Date: 2015-03-13 Impact factor: 2.503
Authors: David J Thomson; David Palma; Matthias Guckenberger; Panagiotis Balermpas; Jonathan J Beitler; Pierre Blanchard; David Brizel; Wilfred Budach; Jimmy Caudell; June Corry; Renzo Corvo; Mererid Evans; Adam S Garden; Jordi Giralt; Vincent Gregoire; Paul M Harari; Kevin Harrington; Ying J Hitchcock; Jorgen Johansen; Johannes Kaanders; Shlomo Koyfman; J A Langendijk; Quynh-Thu Le; Nancy Lee; Danielle Margalit; Michelle Mierzwa; Sandro Porceddu; Yoke Lim Soong; Ying Sun; Juliette Thariat; John Waldron; Sue S Yom Journal: Radiother Oncol Date: 2020-07-27 Impact factor: 6.280
Authors: David J Thomson; David Palma; Matthias Guckenberger; Panagiotis Balermpas; Jonathan J Beitler; Pierre Blanchard; David Brizel; Wilfred Budach; Jimmy Caudell; June Corry; Renzo Corvo; Mererid Evans; Adam S Garden; Jordi Giralt; Vincent Gregoire; Paul M Harari; Kevin Harrington; Ying J Hitchcock; Jorgen Johansen; Johannes Kaanders; Shlomo Koyfman; J A Langendijk; Quynh-Thu Le; Nancy Lee; Danielle Margalit; Michelle Mierzwa; Sandro Porceddu; Yoke Lim Soong; Ying Sun; Juliette Thariat; John Waldron; Sue S Yom Journal: Int J Radiat Oncol Biol Phys Date: 2020-04-14 Impact factor: 7.038