| Literature DB >> 19473841 |
Ikuya Ohno1, Motohiro Tomizawa, Motohiro Tomizawaa, Kathleen A Durkin, John E Casida, Shinzo Kagabu.
Abstract
The bis-pharmacophore approach applied to neonicotinoid insecticides reveals high binding affinity for heptamethylene bis-N(3),N(3')-imidacloprid fitting a nicotinic acetylcholine receptor model wherein the chloropyridine moieties contact loops E and F and the alkylene linker bridges these two distant domains.Entities:
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Year: 2009 PMID： 19473841 DOI： 10.1016/j.bmcl.2009.05.016
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823