| Literature DB >> 19473838 |
Jamal El Bakali1, Frédérique Klupsch, Aurore Guédin, Bertrand Brassart, Gaëlle Fontaine, Amaury Farce, Pascal Roussel, Raymond Houssin, Jean-Luc Bernier, Philippe Chavatte, Jean-Louis Mergny, Jean-François Riou, Jean-Pierre Hénichart.
Abstract
The design and synthesis of 2,6-diphenylthiazolo[3,2-b][1,2,4]triazoles characterized by a large aromatic building block bearing cationic side chains are reported. These molecules are evaluated as telomeric G-quadruplex stabilizers and for their selectivity towards duplex DNA by competition experiments. Two compounds (14a, 19) were found active with high selectivity for telomeric G-quadruplex over duplex DNA.Entities:
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Year: 2009 PMID： 19473838 DOI： 10.1016/j.bmcl.2009.05.025
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823