BACKGROUND AND PURPOSE: It remains uncertain whether current smoking influences outcome in patients with acute ischaemic stroke. OBJECTIVES: To evaluate the effect of current smoking in routinely tissue plasminogen activator (tPA)-treated stroke patients on the 3-month functional outcome and the occurrence of symptomatic intracerebral hemorrhage (ICH). METHODS: We analyzed data from a single stroke care unit registry of 345 consecutive patients with ischaemic stroke, treated with tPA. Logistic regression models were used to assess if smoking was independently associated with 3-months good outcome defined as a modified Rankin Scale score of < or =2, and the occurrence of symptomatic ICH. RESULTS: In the multivariable models, smoking was not associated with a good outcome or a decreased risk of symptomatic ICH. CONCLUSION: Current smoking did not affect functional outcome at 3 months or the risk of symptomatic ICH in patients routinely treated with tPA for ischaemic stroke.
BACKGROUND AND PURPOSE: It remains uncertain whether current smoking influences outcome in patients with acute ischaemic stroke. OBJECTIVES: To evaluate the effect of current smoking in routinely tissue plasminogen activator (tPA)-treated strokepatients on the 3-month functional outcome and the occurrence of symptomatic intracerebral hemorrhage (ICH). METHODS: We analyzed data from a single stroke care unit registry of 345 consecutive patients with ischaemic stroke, treated with tPA. Logistic regression models were used to assess if smoking was independently associated with 3-months good outcome defined as a modified Rankin Scale score of < or =2, and the occurrence of symptomatic ICH. RESULTS: In the multivariable models, smoking was not associated with a good outcome or a decreased risk of symptomatic ICH. CONCLUSION: Current smoking did not affect functional outcome at 3 months or the risk of symptomatic ICH in patients routinely treated with tPA for ischaemic stroke.
Authors: Ju-Hun Lee; Ju Young Lee; So Hyun Ahn; Min Uk Jang; Mi Sun Oh; Chul-Ho Kim; Kyung-Ho Yu; Byung-Chul Lee Journal: J Stroke Date: 2015-05-29 Impact factor: 6.967
Authors: James E Siegler; Muhammad Alvi; Amelia K Boehme; Michael J Lyerly; Karen C Albright; Reza Bavarsad Shahripour; Pawan V Rawal; Niren Kapoor; April Sisson; J Thomas Houston; Anne W Alexandrov; Sheryl Martin-Schild; Andrei V Alexandrov Journal: ISRN Stroke Date: 2013
Authors: Stewart J Wiseman; Fergus N Doubal; Francesca M Chappell; Maria C Valdés-Hernández; Xin Wang; Ann Rumley; Gordon D O Lowe; Martin S Dennis; Joanna M Wardlaw Journal: Cerebrovasc Dis Date: 2015-08-08 Impact factor: 2.762