BACKGROUND: Lung cancer is the leading cause of cancer death for both men and women, but the disease course differs between the sexes. To the authors' knowledge, sex-based differences in outcomes among the population of nonsmall cell lung cancer (NSCLC) patients receiving radiation have not been well defined. METHODS: Data for 831 patients (319 women and 512 men) with stage I to III NSCLC and treated with > or =45 Gray of radiation between March 1985 and November 2003 were retrospectively analyzed (grading determined according to the 1997 American Joint Committee on Cancer grading system). RESULTS: Women were more likely to have earlier stage disease, to have smoked <50 pack-years, and to have adenocarcinoma or large-cell carcinoma (all P < or = .001). For each stage, treatment did not differ between women and men. Five-year survival rates were significantly better for women than for men: overall survival (OS), 28.6% versus 16.1% (P < .001); disease-free survival, 31.2% versus 20.1% (P = .02); and distant metastasis-free survival, 48.8% versus 37.6% (P < .02). Among patients with medically inoperable stage I NSCLC, women had improved 5-year OS compared with men (30.0% vs 13.1%; P = .004). On multivariate analysis, male sex, weight loss, age > or =65 years, and stage III disease were found to be associated with poorer OS (all P < 0.02). CONCLUSIONS: Although women are more likely to have earlier stage disease, among patients with medically inoperable stage I NSCLC, women still have a better OS. Along with known prognostic factors, including age, weight loss, and stage, sex remained significant on multivariate analysis of OS, suggesting that sex is a determinant of outcome in NSCLC patients receiving radiation.
BACKGROUND: Lung cancer is the leading cause of cancer death for both men and women, but the disease course differs between the sexes. To the authors' knowledge, sex-based differences in outcomes among the population of nonsmall cell lung cancer (NSCLC) patients receiving radiation have not been well defined. METHODS: Data for 831 patients (319 women and 512 men) with stage I to III NSCLC and treated with > or =45 Gray of radiation between March 1985 and November 2003 were retrospectively analyzed (grading determined according to the 1997 American Joint Committee on Cancer grading system). RESULTS:Women were more likely to have earlier stage disease, to have smoked <50 pack-years, and to have adenocarcinoma or large-cell carcinoma (all P < or = .001). For each stage, treatment did not differ between women and men. Five-year survival rates were significantly better for women than for men: overall survival (OS), 28.6% versus 16.1% (P < .001); disease-free survival, 31.2% versus 20.1% (P = .02); and distant metastasis-free survival, 48.8% versus 37.6% (P < .02). Among patients with medically inoperable stage I NSCLC, women had improved 5-year OS compared with men (30.0% vs 13.1%; P = .004). On multivariate analysis, male sex, weight loss, age > or =65 years, and stage III disease were found to be associated with poorer OS (all P < 0.02). CONCLUSIONS: Although women are more likely to have earlier stage disease, among patients with medically inoperable stage I NSCLC, women still have a better OS. Along with known prognostic factors, including age, weight loss, and stage, sex remained significant on multivariate analysis of OS, suggesting that sex is a determinant of outcome in NSCLCpatients receiving radiation.
Authors: Sana D Karam; Zachary D Horne; Robert L Hong; Nimrah Baig; Gregory J Gagnon; Don McRae; David Duhamel; Nadim M Nasr Journal: Lung Cancer (Auckl) Date: 2013-08-06
Authors: Sarah Baker; Katerina Bakunina; Marloes Duijm; Mischa S Hoogeman; Robin Cornelissen; Imogeen Antonisse; John Praag; Wilma D Heemsbergen; Joost Jan Nuyttens Journal: Radiat Oncol Date: 2020-04-22 Impact factor: 3.481
Authors: John D Fenwick; David B Landau; Angela T Baker; Andrew T Bates; Chinnamani Eswar; Angel Garcia-Alonso; Susan V Harden; Marianne C Illsley; Virginia Laurence; Zafar Malik; William Philip M Mayles; Elizabeth Miles; Nazia Mohammed; James Spicer; Paula Wells; Sindu Vivekanandan; Anne-Marie Mullin; Laura Hughes; Laura Farrelly; Yenting Ngai; Nicholas Counsell Journal: Int J Radiat Oncol Biol Phys Date: 2019-12-03 Impact factor: 7.038