| Literature DB >> 19472239 |
Peter Schmieder, Ronald Kühne, Jörg Rademann.
Abstract
Metal-free triazole turns: 1,5-Disubstituted peptidyl triazoles are obtained regioselectively from the 1,3-dipolar cycloaddition of peptidyl phosphoranes and azides. Peptide turns are thus formed that contain a conformationally locked cis peptide bond. Being regioselective and free of heavy metals, this reaction may find broad application in chemical biology and medicinal chemistry.Entities:
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Year: 2009 PMID： 19472239 DOI： 10.1002/anie.200806390
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336