OBJECTIVE: The aim of this study was to determine whether the presence of bacterial vaginosis (BV) is associated with cervical intraepithelial neoplasia (CIN) and human papilloma virus (HPV) infection. METHODS: A total of 588 women who had abnormal Pap smears and had finally undergone loop electrosurgical excision procedure (LEEP) in our institute from September 2002 to May 2006 were selected. The screening tests for BV were done in 552 of the 588, and BV was diagnosed if three of the following four findings were satisfied: presence of abnormal discharge, vaginal pH>4.5, presence of clue cells, positive amine or whiff test. Five hundred and five patients had HPV typing tests by the HPV DNA chip. Forty two patients diagnosed with invasive cancer were excluded from this study. CIN was subdivided into low-grade CIN (CIN I) and high-grade CIN (CIN II/III) groups. RESULTS: There was no statistically significant difference in patient characteristics between BV-present and BV-absent group. The incidence of CIN was significantly higher in the BV-present group (p=0.043), however, no statistical significance of BV on CIN was observed on multivariate analysis. HPV infection showed no significant relationship with BV. BV with or without HPV infection did not influence the incidence of CIN, regardless of the severity. CONCLUSION: There was significant correlation between BV and the presence of CIN, regardless of the severity of CIN. In addition, there was no significant association between the presence of BV and HPV infection.
OBJECTIVE: The aim of this study was to determine whether the presence of bacterial vaginosis (BV) is associated with cervical intraepithelial neoplasia (CIN) and human papilloma virus (HPV) infection. METHODS: A total of 588 women who had abnormal Pap smears and had finally undergone loop electrosurgical excision procedure (LEEP) in our institute from September 2002 to May 2006 were selected. The screening tests for BV were done in 552 of the 588, and BV was diagnosed if three of the following four findings were satisfied: presence of abnormal discharge, vaginal pH>4.5, presence of clue cells, positive amine or whiff test. Five hundred and five patients had HPV typing tests by the HPV DNA chip. Forty two patients diagnosed with invasive cancer were excluded from this study. CIN was subdivided into low-grade CIN (CIN I) and high-grade CIN (CIN II/III) groups. RESULTS: There was no statistically significant difference in patient characteristics between BV-present and BV-absent group. The incidence of CIN was significantly higher in the BV-present group (p=0.043), however, no statistical significance of BV on CIN was observed on multivariate analysis. HPV infection showed no significant relationship with BV. BV with or without HPV infection did not influence the incidence of CIN, regardless of the severity. CONCLUSION: There was significant correlation between BV and the presence of CIN, regardless of the severity of CIN. In addition, there was no significant association between the presence of BV and HPV infection.
Entities:
Keywords:
Bacterial vaginosis; Cervical intraepithelial neoplasia; Human papilloma virus
Authors: D A Eschenbach; P R Davick; B L Williams; S J Klebanoff; K Young-Smith; C M Critchlow; K K Holmes Journal: J Clin Microbiol Date: 1989-02 Impact factor: 5.948
Authors: A Frega; P Stentella; G Spera; S Pace; L Cipriano; D Di Ruzza; C Villani; A Pachì Journal: Eur J Gynaecol Oncol Date: 1997 Impact factor: 0.196
Authors: S L Hillier; R P Nugent; D A Eschenbach; M A Krohn; R S Gibbs; D H Martin; M F Cotch; R Edelman; J G Pastorek; A V Rao Journal: N Engl J Med Date: 1995-12-28 Impact factor: 91.245
Authors: J C Borgogna; M D Shardell; E K Santori; T M Nelson; J M Rath; E D Glover; J Ravel; P E Gravitt; C J Yeoman; R M Brotman Journal: BJOG Date: 2019-11-20 Impact factor: 6.531
Authors: Evy Gillet; Joris F A Meys; Hans Verstraelen; Rita Verhelst; Philippe De Sutter; Marleen Temmerman; Davy Vanden Broeck Journal: PLoS One Date: 2012-10-02 Impact factor: 3.240
Authors: Brian J Morris; Ronald H Gray; Xavier Castellsague; F Xavier Bosch; Daniel T Halperin; Jake H Waskett; Catherine A Hankins Journal: Adv Urol Date: 2011-05-22
Authors: Caroline C King; Denise J Jamieson; Jeffrey Wiener; Susan Cu-Uvin; Robert S Klein; Anne M Rompalo; Keerti V Shah; Jack D Sobel Journal: Infect Dis Obstet Gynecol Date: 2011-08-16