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Literature DB >> 19471650

Gynecologic oncology group trials in uterine corpus malignancies: recent progress.

Abstract

The Gynecologic Oncology Group (GOG) has conducted multiple trials related to malignancies of the uterine corpus. Recently, several of these trials have been presented and/or published. Areas of focus included the feasibility of laparoscopic staging for endometrial cancer, the adjuvant management of locally advanced endometrial cancer, whole abdominal irradiation in maximally resected advanced endometrial carcinoma, and combination chemotherapy regimens for stage I and II carcinosarcoma after primary surgery and for advanced or recurrent carcinosarcoma. This article will discuss the background and details of each of these important advances.

Entities: Disease

Keywords: Carcinosarcoma; Clinical trial; Endometrial neoplasm

Year: 2008 PMID： 19471650 PMCID： PMC2676480 DOI： 10.3802/jgo.2008.19.4.218

Source DB: PubMed Journal: J Gynecol Oncol ISSN： 2005-0380 Impact factor: 4.401

10 in total

1. Adjuvant ifosfamide and cisplatin in patients with completely resected stage I or II carcinosarcomas (mixed mesodermal tumors) of the uterus: a Gynecologic Oncology Group study.

Authors: Gregory Sutton; James Kauderer; Linda F Carson; Samuel S Lentz; Charles W Whitney; Holly Gallion
Journal: Gynecol Oncol Date: 2005-03 Impact factor: 5.482

2. Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group Study.

Authors: Marcus E Randall; Virginia L Filiaci; Hyman Muss; Nick M Spirtos; Robert S Mannel; Jeffrey Fowler; J Tate Thigpen; Jo Ann Benda
Journal: J Clin Oncol Date: 2005-12-05 Impact factor: 44.544

3. Randomized trial results of quality of life comparing whole abdominal irradiation and combination chemotherapy in advanced endometrial carcinoma: A gynecologic oncology group study.

Authors: Deborah Watkins Bruner; Andrea Barsevick; Chunqiao Tian; Marcus Randall; Robert Mannel; David E Cohn; Joel Sorosky; Nick M Spirtos
Journal: Qual Life Res Date: 2006-10-11 Impact factor: 4.147

4. A phase III trial of ifosfamide with or without cisplatin in carcinosarcoma of the uterus: A Gynecologic Oncology Group Study.

Authors: G Sutton; V L Brunetto; L Kilgore; J T Soper; R McGehee; G Olt; S S Lentz; J Sorosky; J G Hsiu
Journal: Gynecol Oncol Date: 2000-11 Impact factor: 5.482

5. Laparoscopic staging in patients with incompletely staged cancers of the uterus, ovary, fallopian tube, and primary peritoneum: a Gynecologic Oncology Group (GOG) study.

Authors: Nick M Spirtos; Scott M Eisekop; Guy Boike; John B Schlaerth; James O Cappellari
Journal: Am J Obstet Gynecol Date: 2005-11 Impact factor: 8.661

6. Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: a Gynecologic Oncology Group Study.

Authors: Howard D Homesley; Virginia Filiaci; Maurie Markman; Pincas Bitterman; Lynne Eaton; Larry C Kilgore; Bradley J Monk; Frederick R Ueland
Journal: J Clin Oncol Date: 2007-02-10 Impact factor: 44.544

7. Whole abdominal radiotherapy in the adjuvant treatment of patients with stage III and IV endometrial cancer: a gynecologic oncology group study.

Authors: Gregory Sutton; Janice H Axelrod; Brian N Bundy; Tapan Roy; Howard D Homesley; John H Malfetano; Borys R Mychalczak; Mary E King
Journal: Gynecol Oncol Date: 2005-06 Impact factor: 5.482

8. A gynecologic oncology group randomized phase III trial of whole abdominal irradiation (WAI) vs. cisplatin-ifosfamide and mesna (CIM) as post-surgical therapy in stage I-IV carcinosarcoma (CS) of the uterus.

Authors: Aaron H Wolfson; Mark F Brady; Thomas Rocereto; Robert S Mannel; Yi-Chun Lee; Robert J Futoran; David E Cohn; Olga B Ioffe
Journal: Gynecol Oncol Date: 2007-09-05 Impact factor: 5.482

9. Phase III trial of doxorubicin with or without cisplatin in advanced endometrial carcinoma: a gynecologic oncology group study.

Authors: J Tate Thigpen; Mark F Brady; Howard D Homesley; John Malfetano; Brent DuBeshter; Robert A Burger; Shu Liao
Journal: J Clin Oncol Date: 2004-10-01 Impact factor: 44.544

10. A randomized phase III trial in advanced endometrial carcinoma of surgery and volume directed radiation followed by cisplatin and doxorubicin with or without paclitaxel: A Gynecologic Oncology Group study.

Authors: Howard D Homesley; Virginia Filiaci; Susan K Gibbons; Harry J Long; David Cella; Nick M Spirtos; Robert T Morris; Koen DeGeest; Roger Lee; Anthony Montag
Journal: Gynecol Oncol Date: 2008-12-23 Impact factor: 5.482