Literature DB >> 1947014

The relative biological effectiveness of 10B-neutron capture therapy for early skin reaction in the hamster.

J Hiratsuka1, H Fukuda, T Kobayashi, H Karashima, K Yoshino, Y Imajo, Y Mishima.   

Abstract

The relative biological effectiveness (RBE) of 10B-neutron capture therapy (BNCT) on skin was analyzed using hamsters. The Kyoto University Research Reactor, which has a very low contamination of gamma rays and fast neutrons, was used as a thermal neutron source. Boron-10-para-boronophenylalanine hydrochloride ([10B]BPA.HCl) was administered to the hamsters. The evolution and time course of early skin reactions were assessed. These reactions were compared with those produced by electron beams. The maximum safe skin doses (no more than moist desquamation) of BNCT and electron beams were established to be 11 and 21 Gy, respectively. The RBE at this single dose with BNCT was found to be 1.94, assuming that the RBE of the gamma rays was 1.0 and each component of BNCT (mixed radiations) was simply additive.

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Year:  1991        PMID： 1947014

Source DB:  PubMed          Journal:  Radiat Res        ISSN： 0033-7587            Impact factor:   2.841


  11 in total

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3.  Boron microlocalization in oral mucosal tissue: implications for boron neutron capture therapy.

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4.  A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy.

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5.  Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget's disease with curative responses.

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Review 6.  Boron Neutron Capture Therapy (BNCT) for Cutaneous Malignant Melanoma Using 10B-p-Boronophenylalanine (BPA) with Special Reference to the Radiobiological Basis and Clinical Results.

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Journal:  Cells       Date:  2021-10-26       Impact factor: 6.600

Review 7.  Response of Normal Tissues to Boron Neutron Capture Therapy (BNCT) with 10B-Borocaptate Sodium (BSH) and 10B-Paraboronophenylalanine (BPA).

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Journal:  Cells       Date:  2021-10-26       Impact factor: 6.600

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10.  Long-term outcome of cutaneous melanoma patients treated with boron neutron capture therapy (BNCT).

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Journal:  J Radiat Res       Date:  2020-11-16       Impact factor: 2.724
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