Literature DB >> 19468851

BioCores: identification of a drug/natural product-based privileged structural motif for small-molecule lead discovery.

Roman Kombarov1, Andrea Altieri, Dmitry Genis, Mikhail Kirpichenok, Valeriy Kochubey, Natalia Rakitina, Zoya Titarenko.   

Abstract

The analysis of known drugs (Comprehensive Medicinal Chemistry database (2008 version): http://www.mdl.com/products/knowledge/medicinal_chem/index.jsp ) and natural products (Koch et al., Proc Natl Acad Sci USA 102:17272-17277, 2008) has led to the identification of privileged saturated and aromatic heterocyclic ring pairs that we have termed as "BioCores." This article explains how the BioCores can be used for the design of novel lead-like scaffolds.

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Year:  2009        PMID： 19468851     DOI： 10.1007/s11030-009-9157-5

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  10 in total

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10.  The properties of known drugs. 1. Molecular frameworks.

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7.  Natural products chemistry: The emerging trends and prospective goals.

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