| Literature DB >> 19467350 |
Kimiko Tatsumi1, Shoji Tsuji, Hideki Miwa, Toshinori Morisaku, Mutsuo Nuriya, Minako Orihara, Kazunari Kaneko, Hideyuki Okano, Masato Yasui.
Abstract
The neurogenic gene Drosophila big brain (bib) has a high sequence homology to aquaporin-4. However, its cellular functions in Drosophila neurogenesis have remained elusive. Here we investigated cell adhesion, and the ion and water permeability of Bib. The adhesive function was examined by a cell aggregation assay using L cells. Bib-transfected L cells formed aggregated clusters, while control-L cells remained as a single cell suspension. Ion permeation was not confirmed in L cells stably expressing Bib. When expressed in COS7 cells, Bib exhibited limited water permeability. This newly found cell adhesive function of Bib may be important for Drosophila neurogenesis.Entities:
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Year: 2009 PMID： 19467350 DOI： 10.1016/j.febslet.2009.05.035
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124