| Literature DB >> 19466009 |
Dvir Yelin, Dan Oron, Stephan Thiberge, Elisha Moses, Yaron Silberberg.
Abstract
A novel method for detection of noble-metal nanoparticles by their nonlinear optical properties is presented and applied for specific labeling of cellular organelles. When illuminated by laser light in resonance with their plasmon frequency these nanoparticles generate an enhanced multiphoton signal. This enhanced signal is measured to obtain a depth-resolved image in a laser scanning microscope setup. Plasmon-resonance images of both live and fixed cells, showing specific labeling of cellular organelles and membranes, either by two-photon autofluorescence or by third-harmonic generation, are presented.Entities:
Year: 2003 PMID: 19466009 DOI: 10.1364/oe.11.001385
Source DB: PubMed Journal: Opt Express ISSN: 1094-4087 Impact factor: 3.894