OBJECTIVE: We analyzed the computed tomography and clinical findings of pulmonary alveolar proteinosis secondary to hematologic malignancy. MATERIALS AND METHODS: Seven patients with hematologic malignancy and pathologically proven secondary pulmonary alveolar proteinosis were identified from 2000 to 2007. Six had chest computed tomography scans, which were analyzed retrospectively; medical records were also reviewed. RESULTS: Patient age ranged from 30 to 54 years. Four had chronic myelogenous leukemia, 1 had myelodysplastic syndrome, and 1 had cutaneous T-cell lymphoma. As in idiopathic pulmonary alveolar proteinosis, geographic ground-glass opacities with or without septal thickening were most common (5/6). No axial or zonal predominance was present. Two patients died from respiratory failure. CONCLUSIONS: It is important to consider secondary pulmonary alveolar proteinosis as a cause of geographic ground-glass opacities and septal thickening in a patient with hematologic malignancy. Whereas idiopathic pulmonary alveolar proteinosis has a low mortality rate, the death of 2 of our 6 patients implies that secondary pulmonary alveolar proteinosis may have a worse prognosis. Our case of secondary pulmonary alveolar proteinosis associated with cutaneous T-cell lymphoma is the first described in the literature.
OBJECTIVE: We analyzed the computed tomography and clinical findings of pulmonary alveolar proteinosis secondary to hematologic malignancy. MATERIALS AND METHODS: Seven patients with hematologic malignancy and pathologically proven secondary pulmonary alveolar proteinosis were identified from 2000 to 2007. Six had chest computed tomography scans, which were analyzed retrospectively; medical records were also reviewed. RESULTS:Patient age ranged from 30 to 54 years. Four had chronic myelogenous leukemia, 1 had myelodysplastic syndrome, and 1 had cutaneous T-cell lymphoma. As in idiopathic pulmonary alveolar proteinosis, geographic ground-glass opacities with or without septal thickening were most common (5/6). No axial or zonal predominance was present. Two patients died from respiratory failure. CONCLUSIONS: It is important to consider secondary pulmonary alveolar proteinosis as a cause of geographic ground-glass opacities and septal thickening in a patient with hematologic malignancy. Whereas idiopathic pulmonary alveolar proteinosis has a low mortality rate, the death of 2 of our 6 patients implies that secondary pulmonary alveolar proteinosis may have a worse prognosis. Our case of secondary pulmonary alveolar proteinosis associated with cutaneous T-cell lymphoma is the first described in the literature.
Authors: Christina Mueller-Mang; Claudia Grosse; Katharina Schmid; Leopold Stiebellehner; Alexander A Bankier Journal: Radiographics Date: 2007 May-Jun Impact factor: 5.333
Authors: U Dirksen; U Hattenhorst; P Schneider; H Schroten; U Göbel; A Böcking; K M Müller; R Murray; S Burdach Journal: Blood Date: 1998-08-15 Impact factor: 22.113
Authors: Katharine Tsukahara; Robert B Lindell; Haley Newman; Benjamin J Lerman; Leslie S Kersun; Joseph Piccione Journal: Pediatr Pulmonol Date: 2021-10-13