| Literature DB >> 19465021 |
Arni E Gambe1, Sachihiro Matsunaga, Hideaki Takata, Rika Ono-Maniwa, Akiko Baba, Susumu Uchiyama, Kiichi Fukui.
Abstract
We report here the functional analysis of human Regulator of Ribosome Synthesis 1 (RRS1) protein during mitosis. We demonstrate that RRS1 localizes in the nucleolus during interphase and is distributed at the chromosome periphery during mitosis. RNA interference experiments revealed that RRS1-depleted cells show abnormalities in chromosome alignment and spindle organization, which result in mitotic delay. RRS1 knockdown also perturbs the centromeric localization of Shugoshin 1 and results in premature separation of sister chromatids. Our results suggest that a nucleolar protein RRS1 contributes to chromosome congression.Entities:
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Year: 2009 PMID： 19465021 DOI： 10.1016/j.febslet.2009.05.033
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124