AIMS: We evaluated if type 1 diabetic patients have altered levels of low-grade inflammatory markers including platelet-activating factor acetylhydrolase (PAF-AH) activity, high-sensitivity C-reactive protein (hs-CRP), white blood cells count (WBC), erythrocyte sedimentation rate (ESR) and LDL-cholesterol oxidation coefficient (OxC), and whether their levels are related to clinical complications and the metabolic profile. METHODS: We studied cross-sectionally 118 outpatients with type 1 diabetes both with (n=38) and without (n=80) clinical chronic complications, and 110 controls subjects. RESULTS: Diabetic patients had higher levels of PAF-AH activity (p=0.02), hs-CRP (p=0.001), WBC (p=0.004) and ESR (p=0.0001) than controls. Patients with type 1 diabetes had earlier OxC than the non-diabetic subjects at 1 and 3 h (p=0.01) after the addition of CuSO(4). No difference was noted between patients with and without chronic complications. In the patients, correlations were found between PAF-AH activity and OxC at 1 and 3 h. CONCLUSIONS: It was concluded that the susceptibility of LDL to in vitro oxidation and low-grade inflammation are increased in patients with type 1 diabetes and related to each other. The presence of these markers is probably independent of the presence of chronic clinical complications and reveals the development of early pro-inflammatory state.
AIMS: We evaluated if type 1 diabeticpatients have altered levels of low-grade inflammatory markers including platelet-activating factor acetylhydrolase (PAF-AH) activity, high-sensitivity C-reactive protein (hs-CRP), white blood cells count (WBC), erythrocyte sedimentation rate (ESR) and LDL-cholesterol oxidation coefficient (OxC), and whether their levels are related to clinical complications and the metabolic profile. METHODS: We studied cross-sectionally 118 outpatients with type 1 diabetes both with (n=38) and without (n=80) clinical chronic complications, and 110 controls subjects. RESULTS:Diabeticpatients had higher levels of PAF-AH activity (p=0.02), hs-CRP (p=0.001), WBC (p=0.004) and ESR (p=0.0001) than controls. Patients with type 1 diabetes had earlier OxC than the non-diabetic subjects at 1 and 3 h (p=0.01) after the addition of CuSO(4). No difference was noted between patients with and without chronic complications. In the patients, correlations were found between PAF-AH activity and OxC at 1 and 3 h. CONCLUSIONS: It was concluded that the susceptibility of LDL to in vitro oxidation and low-grade inflammation are increased in patients with type 1 diabetes and related to each other. The presence of these markers is probably independent of the presence of chronic clinical complications and reveals the development of early pro-inflammatory state.
Authors: Marilia Brito Gomes; Carlos Antonio Negrato; Roberta Cobas; Lucianne Righeti Monteiro Tannus; Paolla Ribeiro Gonçalves; Pedro Carlos Barreto da Silva; João Regis Ivar Carneiro; Alessandra Saldanha Mattos Matheus; Sergio Atala Dib; Mirela Jobim Azevedo; Márcia Nery; Melanie Rodacki; Lenita Zajdenverg; Renan Magalhães Montenegro Junior; Janice Sepulveda; Luis Eduardo Calliari; Deborah Jezini; Neuza Braga; Jorge L Luescher; Renata S Berardo; Maria Carmo Arruda-Marques; Renata M Noronha; Thais D Manna; Roberta Salvodelli; Fernanda G Penha; Milton C Foss; Maria C Foss-Freitas; Antonio C Pires; Fernando C Robles; Maria de Fátima S Guedes; Patricia Dualib; Saulo C Silva; Emerson Sampaio; Rosangela Rea; Ana Cristina R Faria; Balduino Tschiedel; Suzana Lavigne; Luis Henrique Canani; Alessandra T Zucatti; Marisa Helena C Coral; Daniela Aline Pereira; Luiz Antonio Araujo; Monica Tolentino; Hermelinda C Pedrosa; Flaviane A Prado; Nelson Rassi; Leticia B Araujo; Reine Marie C Fonseca; Alexis D Guedes; Odelissa S Matos; Catia C Palma; Rossana Azulay; Adriana C Forti; Cristina Façanha; Ana Paula Montenegro; Naira H Melo; Karla F Rezende; Alberto Ramos; João Soares Felicio; Flavia M Santos Journal: Diabetol Metab Syndr Date: 2014-05-31 Impact factor: 3.320
Authors: Alessandra Saldanha de Mattos Matheus; Lucianne Righeti Monteiro Tannus; Roberta Arnoldi Cobas; Catia C Sousa Palma; Carlos Antonio Negrato; Marilia de Brito Gomes Journal: Int J Hypertens Date: 2013-03-04 Impact factor: 2.420