Literature DB >> 1946361

Crystal structure of recombinant human T-cell cyclophilin A at 2.5 A resolution.

H M Ke1, L D Zydowsky, J Liu, C T Walsh.   

Abstract

The structure of the unligated human T-cell recombinant cyclophilin has been determined at 3 A resolution by multipole isomorphous replacement methods and refined at 2.5 A resolution to an R factor of 0.209. The root-mean-square errors of the bond lengths and bond angles are 0.013 A and 2.8 degrees from ideal geometry, respectively. The overall structure is a beta-barrel, consisting of eight antiparallel beta-strands wrapping around the barrel surface and two alpha-helices sitting on the top and the bottom closing the barrel. Inside the barrel, seven aromatic and other hydrophobic residues form a compact hydrophobic core. A loop of Lys-118 to His-126 and four beta-strands (B3-B6) constitute a pocket we speculate to be the binding site of cyclosporin A.

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Year:  1991        PMID： 1946361      PMCID： PMC52742          DOI： 10.1073/pnas.88.21.9483

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

1.  Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.

Authors:  S W Michnick; M K Rosen; T J Wandless; M Karplus; S L Schreiber
Journal:  Science       Date:  1991-05-10       Impact factor: 47.728

2.  A second cyclophilin-related gene in Saccharomyces cerevisiae.

Authors:  P L Koser; D Sylvester; G P Livi; D J Bergsma
Journal:  Nucleic Acids Res       Date:  1990-03-25       Impact factor: 16.971

3.  1H NMR studies on bovine cyclophilin: preliminary structural characterization of this specific cyclosporin A binding protein.

Authors:  D C Dalgarno; M W Harding; A Lazarides; R E Handschumacher; I M Armitage
Journal:  Biochemistry       Date:  1986-11-04       Impact factor: 3.162

4.  Orthogonal packing of beta-pleated sheets in proteins.

Authors:  C Chothia; J Janin
Journal:  Biochemistry       Date:  1982-08-17       Impact factor: 3.162

Review 5.  The anatomy and taxonomy of protein structure.

Authors:  J S Richardson
Journal:  Adv Protein Chem       Date:  1981

6.  Human and Escherichia coli cyclophilins: sensitivity to inhibition by the immunosuppressant cyclosporin A correlates with a specific tryptophan residue.

Authors:  J Liu; C M Chen; C T Walsh
Journal:  Biochemistry       Date:  1991-03-05       Impact factor: 3.162

7.  The structure of beta-lactoglobulin and its similarity to plasma retinol-binding protein.

Authors:  M Z Papiz; L Sawyer; E E Eliopoulos; A C North; J B Findlay; R Sivaprasadarao; T A Jones; M E Newcomer; P J Kraulis
Journal:  Nature       Date:  1986 Nov 27-Dec 3       Impact factor: 49.962

8.  Isolation and amino acid sequence of cyclophilin.

Authors:  M W Harding; R E Handschumacher; D W Speicher
Journal:  J Biol Chem       Date:  1986-06-25       Impact factor: 5.157

9.  Cyclophilin: a specific cytosolic binding protein for cyclosporin A.

Authors:  R E Handschumacher; M W Harding; J Rice; R J Drugge; D W Speicher
Journal:  Science       Date:  1984-11-02       Impact factor: 47.728

10.  The ninaA gene required for visual transduction in Drosophila encodes a homologue of cyclosporin A-binding protein.

Authors:  B H Shieh; M A Stamnes; S Seavello; G L Harris; C S Zuker
Journal:  Nature       Date:  1989-03-02       Impact factor: 49.962
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  49 in total

1.  Structural consequences of cyclophilin A binding on maturational refolding in human immunodeficiency virus type 1 capsid protein.

Authors:  L Dietrich; L S Ehrlich; T J LaGrassa; D Ebbets-Reed; C Carter
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

Review 2.  Peptidyl-prolyl isomerases: a new twist to transcription.

Authors:  Peter E Shaw
Journal:  EMBO Rep       Date:  2002-06       Impact factor: 8.807

3.  A molecular dynamics study of Cyclophilin A free and in complex with the Ala-Pro dipeptide.

Authors:  Pekka Mark; Lennart Nilsson
Journal:  Eur Biophys J       Date:  2007-01-16       Impact factor: 1.733

Review 4.  Identification of HIV inhibitors guided by free energy perturbation calculations.

Authors:  Orlando Acevedo; Zandrea Ambrose; Patrick T Flaherty; Hadega Aamer; Prashi Jain; Somisetti V Sambasivarao
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

5.  The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein.

Authors:  D Braaten; H Ansari; J Luban
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

6.  Delineation of the calcineurin-interacting region of cyclophilin B.

Authors:  M Carpentier; F Allain; B Haendler; M C Slomianny; G Spik
Journal:  Protein Sci       Date:  2000-12       Impact factor: 6.725

Review 7.  Host-targeting agents in the treatment of hepatitis C: a beginning and an end?

Authors:  James M Baugh; Jose A Garcia-Rivera; Philippe A Gallay
Journal:  Antiviral Res       Date:  2013-09-30       Impact factor: 5.970

8.  A cyclophilin from the polycentric anaerobic rumen fungus Orpinomyces sp. strain PC-2 is highly homologous to vertebrate cyclophilin B.

Authors:  H Chen; X L Li; L G Ljungdahl
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

9.  X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain.

Authors:  V Mikol; J Kallen; M D Walkinshaw
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

10.  Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition.

Authors:  L D Zydowsky; F A Etzkorn; H Y Chang; S B Ferguson; L A Stolz; S I Ho; C T Walsh
Journal:  Protein Sci       Date:  1992-09       Impact factor: 6.725
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