OBJECTIVE: Although a 5%-10% loss in the baseline weight has been associated with improvement in obesity-related disorders, only a few studies have explored the factors to alleviate metabolic syndrome (MS). This study aimed to determine the factors that alter MS components in overweight Japanese women. METHODS: Between 1999 and 2006, 323 Japanese women aged 24-67 with body mass indices of 25-40 kg/m(2) and the presence of at least 1 component of MS were recruited from Ibaraki and Chiba. The participants were enrolled in a 3-month weight-loss program with a low-calorie diet with or without exercise. The factors to alleviate MS components were explored using classification and regression tree (CART) analyses. RESULTS: Of the 323 participants, 309 completed the weight-loss program and were included in the analyses. The CART analyses revealed that a weight reduction of 8.1% in baseline body weight was sufficient to improve at least 1 component of MS. Similarly, classification trees were generated for improvement in abdominal obesity (essential factor: > or =13.0% weight loss), hypertension (essential factor: baseline age, < or =41.5 years), and hyperglycemia (essential factor: > or =13.2% weight loss). CONCLUSION: These results suggest that moderate weight loss of 8%-13% contributes to improving the MS components in overweight Japanese women.
OBJECTIVE: Although a 5%-10% loss in the baseline weight has been associated with improvement in obesity-related disorders, only a few studies have explored the factors to alleviate metabolic syndrome (MS). This study aimed to determine the factors that alter MS components in overweight Japanese women. METHODS: Between 1999 and 2006, 323 Japanese women aged 24-67 with body mass indices of 25-40 kg/m(2) and the presence of at least 1 component of MS were recruited from Ibaraki and Chiba. The participants were enrolled in a 3-month weight-loss program with a low-calorie diet with or without exercise. The factors to alleviate MS components were explored using classification and regression tree (CART) analyses. RESULTS: Of the 323 participants, 309 completed the weight-loss program and were included in the analyses. The CART analyses revealed that a weight reduction of 8.1% in baseline body weight was sufficient to improve at least 1 component of MS. Similarly, classification trees were generated for improvement in abdominal obesity (essential factor: > or =13.0% weight loss), hypertension (essential factor: baseline age, < or =41.5 years), and hyperglycemia (essential factor: > or =13.2% weight loss). CONCLUSION: These results suggest that moderate weight loss of 8%-13% contributes to improving the MS components in overweight Japanese women.
Authors: Su Yon Jung; Mara Z Vitolins; Jenifer Fenton; Alexis C Frazier-Wood; Stephen D Hursting; Shine Chang Journal: PLoS One Date: 2015-03-30 Impact factor: 3.240