José Pontón1. 1. Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Vizcaya, España. jose.ponton@ehu.es
Abstract
BACKGROUND: The laboratory diagnosis of invasive candidiasis is based on the demonstration of tissue invasion by Candida, the culture of the fungus in specimens from sterile body sites and the detection of a number of biomarkers including some antibodies, mannan, beta-1,3-D-glucan and Candida DNA. AIMS: Description and evaluation of results obtained in published studies on the usefulness of biomarkers in the diagnosis of invasive candidiasis. METHODS: A search was performed in the PubMed/Medline database from the National Library of Medicine since January 2000 on the usefulness of biomarkers in the diagnosis of invasive candidiasis. Key words used included candidiasis, Candida, diagnosis, biomarkers, antigen, antibodies, DNA, mannan, and beta-1,3-D-glucan. RESULTS: Forty one papers dealing with the use of biomarkers in the diagnosis of invasive candidiasis were selected and evaluated, paying special attention to the sensitivity and specificity obtained with the tests used. CONCLUSIONS: Important advances are being reached in the use of biomarkers for the diagnosis of invasive candidiasis, and some of them are being used to start a preemptive therapy strategy.
BACKGROUND: The laboratory diagnosis of invasive candidiasis is based on the demonstration of tissue invasion by Candida, the culture of the fungus in specimens from sterile body sites and the detection of a number of biomarkers including some antibodies, mannan, beta-1,3-D-glucan and Candida DNA. AIMS: Description and evaluation of results obtained in published studies on the usefulness of biomarkers in the diagnosis of invasive candidiasis. METHODS: A search was performed in the PubMed/Medline database from the National Library of Medicine since January 2000 on the usefulness of biomarkers in the diagnosis of invasive candidiasis. Key words used included candidiasis, Candida, diagnosis, biomarkers, antigen, antibodies, DNA, mannan, and beta-1,3-D-glucan. RESULTS: Forty one papers dealing with the use of biomarkers in the diagnosis of invasive candidiasis were selected and evaluated, paying special attention to the sensitivity and specificity obtained with the tests used. CONCLUSIONS: Important advances are being reached in the use of biomarkers for the diagnosis of invasive candidiasis, and some of them are being used to start a preemptive therapy strategy.
Authors: H Teixeira; L Silva; J J F Magalhães; C Matias; J F F Magalhães; J M A Lyra; V Magalhães; N Lucena-Silva; H R L Melo; M B Jucá; C A A Brito Journal: Support Care Cancer Date: 2014-06-05 Impact factor: 3.603