Literature DB >> 19460867

Dicer independent small RNAs associate with telomeric heterochromatin.

Fang Cao1, Xiangzhi Li, Samantha Hiew, Hugh Brady, Yifan Liu, Yali Dou.   

Abstract

Small RNAs play important roles in the establishment and maintenance of heterochromatin structures. We show the presence of telomere specific small RNAs (tel-sRNAs) in mouse embryonic stem cells that are approximately 24 nucleotides in length, Dicer-independent, and 2'-O-methylated at the 3' terminus. The tel-sRNAs are asymmetric with specificity toward telomere G-rich strand, and evolutionarily conserved from protozoan to mammalian cells. Furthermore, tel-sRNAs are up-regulated in cells that carry null mutation of H3K4 methyltransferase MLL (Mll((-/-))) and down-regulated in cells that carry null mutations of histone H3K9 methyltransferase SUV39H (Suv39h1/h2((-/-))), suggesting that they are subject to epigenetic regulation. These results support that tel-sRNAs are heterochromatin associated pi-like small RNAs.

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Year:  2009        PMID： 19460867      PMCID： PMC2704082          DOI： 10.1261/rna.1423309

Source DB:  PubMed          Journal:  RNA        ISSN： 1355-8382            Impact factor:   4.942


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