| Literature DB >> 19460431 |
Julia Zaitseva1, Vladimir Granik, Alexandr Belik, Olga Koksharova, Inessa Khmel.
Abstract
Antibacterial drugs in the nitrofuran series, such as nitrofurazone, furazidin, nitrofurantoin and nifuroxazide, as well as the nitric oxide generators sodium nitroprusside and isosorbide mononitrate in concentrations that do not suppress bacterial growth, were shown to increase the capacity of pathogenic bacteria Pseudomonas aeruginosa PAO1 and Burkholderia cenocepacia 370 to form biofilms. At 25-100microg/ml, nitrofurans 2-2.5-fold enhanced biofilm formation of P. aeruginosa PAO1, and NO donors 3-6-fold. For B. cenocepacia 370, the enhancement was 2-5-fold (nitrofurans) and 4.5-fold (sodium nitroprusside), respectively.Entities:
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Year: 2009 PMID： 19460431 DOI： 10.1016/j.resmic.2009.04.007
Source DB: PubMed Journal: Res Microbiol ISSN： 0923-2508 Impact factor: 3.992