OBJECTIVE: To evaluate the results of autologous chondrocytes implantation in the patients with large traumatic cartilage defects of the knee. MATERIAL AND METHOD: Five patients (six knees) with grade 3-4 according to International Cartilage Repair Society Classification System were performed ACI between May 2006 and April 2007. The two-stage procedure was performed. First, the cartilage was arthroscopic harvested. The chondrocytes were isolated in the laboratory. Second, the chondrocytes were re-implanted into the defects. The patients were clinically evaluated preoperatively and postoperatively with Knee and Osteoarthritis Outcome Score (KOOS), magnetic resonance imaging, and arthroscopic assessment. The mean duration of follow-up was 19.8 +/- 4.6 months. RESULTS: There was no postoperative complication. The clinical evaluation with Knee and Osteoarthritis Outcome Score (KOOS) showed significant improvement. The MRI showed the filling of regenerative cartilage tissue formation at the defects. The arthroscopic assessment showed the good defect fill, stiffness, and incorporation to the adjacent cartilage. CONCLUSION: The autologous chondrocytes implantation showed the potential for the treatment of large cartilage defects. The excellent results allowed patients to return to normal activity level.
OBJECTIVE: To evaluate the results of autologous chondrocytes implantation in the patients with large traumatic cartilage defects of the knee. MATERIAL AND METHOD: Five patients (six knees) with grade 3-4 according to International Cartilage Repair Society Classification System were performed ACI between May 2006 and April 2007. The two-stage procedure was performed. First, the cartilage was arthroscopic harvested. The chondrocytes were isolated in the laboratory. Second, the chondrocytes were re-implanted into the defects. The patients were clinically evaluated preoperatively and postoperatively with Knee and Osteoarthritis Outcome Score (KOOS), magnetic resonance imaging, and arthroscopic assessment. The mean duration of follow-up was 19.8 +/- 4.6 months. RESULTS: There was no postoperative complication. The clinical evaluation with Knee and Osteoarthritis Outcome Score (KOOS) showed significant improvement. The MRI showed the filling of regenerative cartilage tissue formation at the defects. The arthroscopic assessment showed the good defect fill, stiffness, and incorporation to the adjacent cartilage. CONCLUSION: The autologous chondrocytes implantation showed the potential for the treatment of large cartilage defects. The excellent results allowed patients to return to normal activity level.
Authors: Juan Zhong; Bin Guo; Jing Xie; Shuwen Deng; Na Fu; Shiyu Lin; Guo Li; Yunfeng Lin; Xiaoxiao Cai Journal: Bone Res Date: 2016-02-03 Impact factor: 13.567