Literature DB >> 19459019

Colorectal surgical specimen lymph node harvest: improvement of lymph node yield with a pathology assistant.

Jeffery A Reese1, Christopher Hall, Kelly Bowles, Robert C Moesinger.   

Abstract

INTRODUCTION: Adequate lymph node harvest from colorectal cancer specimens has become a standard of care, influencing both staging and survival. To improve lymph node harvests at our hospital, a pathology assistant was trained to meticulously harvest lymph nodes from colorectal cancer specimens. An analysis of trends in lymph node harvests over time is presented.
METHODS: The number of harvested lymph nodes from 391 consecutive colorectal cancer pathology reports was retrospectively reviewed from a single community hospital over 8 years (1999-2006). This spanned 4 years prior to the training of the pathology assistant and 4 years after.
RESULTS: From 1999-2002, the mean number of harvested lymph nodes varied from 12.2 to 14.4. The percentage of specimens achieving 12 lymph nodes was 50-67%. From 2003-2006, the mean number of harvested lymph nodes increased to 18.4-20.7, while the percentage of specimens achieving 12 lymph nodes was 83-87%. Both of these improvements achieved statistical significance with p values of <0.00001.
CONCLUSIONS: Over time, lymph node harvests at our hospital dramatically improved. The training of a pathology assistant to harvest the lymph nodes from colorectal cancer specimens dramatically affected lymph node harvests and can be a crucial component of pathologic analysis of these specimens.

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Year:  2009        PMID: 19459019     DOI: 10.1007/s11605-009-0820-z

Source DB:  PubMed          Journal:  J Gastrointest Surg        ISSN: 1091-255X            Impact factor:   3.452


  17 in total

1.  Practice parameters for colon cancer.

Authors:  Daniel Otchy; Neil H Hyman; Clifford Simmang; Thomas Anthony; W Donald Buie; Peter Cataldo; James Church; Jeffrey Cohen; Frederick Dentsman; C Neal Ellis; John W Kilkenny; Clifford Ko; Richard Moore; Charles Orsay; Ronald Place; Janice Rafferty; Jan Rakinic; Paul Savoca; Joe Tjandra; Mark Whiteford
Journal:  Dis Colon Rectum       Date:  2004-08       Impact factor: 4.585

2.  Increasing negative lymph node count is independently associated with improved long-term survival in stage IIIB and IIIC colon cancer.

Authors:  Paul M Johnson; Geoff A Porter; Rocco Ricciardi; Nancy N Baxter
Journal:  J Clin Oncol       Date:  2006-08-01       Impact factor: 44.544

3.  Number of lymph nodes examined and its impact on colorectal cancer staging.

Authors:  Justin Kim; Richard Huynh; Iype Abraham; Eddie Kim; Ravin R Kumar
Journal:  Am Surg       Date:  2006-10       Impact factor: 0.688

Review 4.  Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999.

Authors:  C C Compton; L P Fielding; L J Burgart; B Conley; H S Cooper; S R Hamilton; M E Hammond; D E Henson; R V Hutter; R B Nagle; M L Nielsen; D J Sargent; C R Taylor; M Welton; C Willett
Journal:  Arch Pathol Lab Med       Date:  2000-07       Impact factor: 5.534

5.  Colon cancer survival is associated with decreasing ratio of metastatic to examined lymph nodes.

Authors:  Adam C Berger; Elin R Sigurdson; Thomas LeVoyer; Alexandra Hanlon; Robert J Mayer; John S Macdonald; Paul J Catalano; Daniel G Haller
Journal:  J Clin Oncol       Date:  2005-12-01       Impact factor: 44.544

6.  The impact of surgeon and pathologist on lymph node retrieval in colorectal cancer and its impact on survival for patients with Dukes' stage B disease.

Authors:  M D Evans; K Barton; A Rees; J D Stamatakis; S S Karandikar
Journal:  Colorectal Dis       Date:  2007-03-07       Impact factor: 3.788

7.  Association of demographic and treatment variables in long-term colon cancer survival.

Authors:  Amy E Lincourt; Ronald F Sing; Kent W Kercher; Andrew Stewart; Bradley L Demeter; William W Hope; Nicholas P Lang; B Todd Heniford
Journal:  Surg Innov       Date:  2008-04-02       Impact factor: 2.058

8.  Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089.

Authors:  T E Le Voyer; E R Sigurdson; A L Hanlon; R J Mayer; J S Macdonald; P J Catalano; D G Haller
Journal:  J Clin Oncol       Date:  2003-08-01       Impact factor: 44.544

9.  Hospital lymph node examination rates and survival after resection for colon cancer.

Authors:  Sandra L Wong; Hong Ji; Brent K Hollenbeck; Arden M Morris; Onur Baser; John D Birkmeyer
Journal:  JAMA       Date:  2007-11-14       Impact factor: 56.272

10.  Factors affecting the number of lymph nodes retrieved in colorectal cancer specimens.

Authors:  Michelle A Ostadi; Julie L Harnish; Stacey Stegienko; David R Urbach
Journal:  Surg Endosc       Date:  2007-05-24       Impact factor: 4.584

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  9 in total

1.  Lymph node yield after colectomy for cancer: is absence of mismatch repair a factor?

Authors:  Tushar Samdani; Molly Schultheis; Zsofia Stadler; Jinru Shia; Tiffany Fancher; Justine Misholy; Martin R Weiser; Garrett M Nash
Journal:  Dis Colon Rectum       Date:  2015-03       Impact factor: 4.585

2.  Influence of socioeconomic status and hospital type on disparities of lymph node evaluation in colon cancer patients.

Authors:  Mei-Chin Hsieh; Cruz Velasco; Xiao-Cheng Wu; Lisa A Pareti; Patricia A Andrews; Vivien W Chen
Journal:  Cancer       Date:  2011-08-31       Impact factor: 6.860

3.  Does body mass index impact the number of LNs harvested and influence long-term survival rate in patients with stage III colon cancer?

Authors:  Yi-Hung Kuo; Kam-Fai Lee; Chih-Chien Chin; Wen-Shih Huang; Chung-Hung Yeh; Jeng-Yi Wang
Journal:  Int J Colorectal Dis       Date:  2012-05-25       Impact factor: 2.571

4.  Factors affecting lymph node yield from patients undergoing colectomy for cancer.

Authors:  Zubin M Bamboat; Danielle Deperalta; Abdulmetin Dursun; David L Berger; Liliana Bordeianou
Journal:  Int J Colorectal Dis       Date:  2011-05-15       Impact factor: 2.571

Review 5.  Pathologist's assistant (PathA) and his/her role in the surgical pathology department: a systematic review and a narrative synthesis.

Authors:  M Bortesi; V Martino; M Marchetti; A Cavazza; G Gardini; E Zanetti; M C Bassi; L Ghirotto; M Costantini; Simonetta Piana
Journal:  Virchows Arch       Date:  2018-01-29       Impact factor: 4.064

6.  The re-evaluation of optimal lymph node yield in stage II right-sided colon cancer: is a minimum of 12 lymph nodes adequate?

Authors:  Yibo Cai; Guoping Cheng; Xingang Lu; Haixing Ju; Xiu Zhu
Journal:  Int J Colorectal Dis       Date:  2020-01-30       Impact factor: 2.571

7.  Extended lymph node dissection in colorectal cancer surgery. Reliability and reproducibility in assessments of operative reports.

Authors:  Kjell Ovrebo; Ola Rokke
Journal:  Int J Colorectal Dis       Date:  2009-10-29       Impact factor: 2.571

8.  Colon cancer lymph node evaluation among military health system beneficiaries: an analysis by race/ethnicity.

Authors:  Abegail A Gill; Shelia H Zahm; Craig D Shriver; Alexander Stojadinovic; Katherine A McGlynn; Kangmin Zhu
Journal:  Ann Surg Oncol       Date:  2014-07-25       Impact factor: 5.344

Review 9.  Assessment of lymph node involvement in colorectal cancer.

Authors:  Mark L H Ong; John B Schofield
Journal:  World J Gastrointest Surg       Date:  2016-03-27
  9 in total

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