Literature DB >> 19457860

Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family.

Hans Henrik Gad1, Christoffer Dellgren, Ole J Hamming, Susanne Vends, Søren R Paludan, Rune Hartmann.   

Abstract

Interferon-lambda (IFN-lambda) is an antiviral cytokine that signals through a distinct receptor complex, composed of the IFN-lambdaR1 and interleukin-10R2 (IL-10R2) receptor chains. We have determined the crystal structure of human IFN-lambda3 and characterized the interaction with its receptor complex through structure-based site-directed mutagenesis. The ability of IFN-lambda3 mutants to signal was determined by measuring the antiviral activity and induced STAT2 phosphorylation. In conclusion, our data show that, although IFN-lambda is functionally an interferon, it is clearly structurally related to members of the IL-10 family. In particular, we found an interesting similarity between IFN-lambda and IL-22, and we suggest that IFN-lambda and IL-22 possess parallel functions, protecting epithelial tissue against viral and bacterial infections, respectively.

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Year:  2009        PMID： 19457860      PMCID： PMC2742852          DOI： 10.1074/jbc.M109.002923

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  35 in total

1.  IL-28, IL-29 and their class II cytokine receptor IL-28R.

Authors:  Paul Sheppard; Wayne Kindsvogel; Wenfeng Xu; Katherine Henderson; Stacy Schlutsmeyer; Theodore E Whitmore; Rolf Kuestner; Ursula Garrigues; Carl Birks; Jenny Roraback; Craig Ostrander; Dennis Dong; Jinu Shin; Scott Presnell; Brian Fox; Betty Haldeman; Emily Cooper; David Taft; Teresa Gilbert; Francis J Grant; Monica Tackett; William Krivan; Gary McKnight; Chris Clegg; Don Foster; Kevin M Klucher
Journal:  Nat Immunol       Date:  2002-12-02       Impact factor: 25.606

2.  PHENIX: building new software for automated crystallographic structure determination.

Authors:  Paul D Adams; Ralf W Grosse-Kunstleve; Li Wei Hung; Thomas R Ioerger; Airlie J McCoy; Nigel W Moriarty; Randy J Read; James C Sacchettini; Nicholas K Sauter; Thomas C Terwilliger
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2002-10-21

3.  The IL-10R2 binding hot spot on IL-22 is located on the N-terminal helix and is dependent on N-linked glycosylation.

Authors:  Naomi J Logsdon; Brandi C Jones; Jennifer C Allman; Lara Izotova; Barbara Schwartz; Sidney Pestka; Mark R Walter
Journal:  J Mol Biol       Date:  2004-09-10       Impact factor: 5.469

4.  Coot: model-building tools for molecular graphics.

Authors:  Paul Emsley; Kevin Cowtan
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2004-11-26

5.  IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.

Authors:  Sergei V Kotenko; Grant Gallagher; Vitaliy V Baurin; Anita Lewis-Antes; Meiling Shen; Nital K Shah; Jerome A Langer; Faruk Sheikh; Harold Dickensheets; Raymond P Donnelly
Journal:  Nat Immunol       Date:  2002-12-16       Impact factor: 25.606

6.  Lambda interferon inhibits hepatitis B and C virus replication.

Authors:  Michael D Robek; Bryan S Boyd; Francis V Chisari
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

7.  Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site.

Authors:  K Josephson; N J Logsdon; M R Walter
Journal:  Immunity       Date:  2001-07       Impact factor: 31.745

Review 8.  Interleukin-10 and related cytokines and receptors.

Authors:  Sidney Pestka; Christopher D Krause; Devanand Sarkar; Mark R Walter; Yufang Shi; Paul B Fisher
Journal:  Annu Rev Immunol       Date:  2004       Impact factor: 28.527

Review 9.  Interferons, interferon-like cytokines, and their receptors.

Authors:  Sidney Pestka; Christopher D Krause; Mark R Walter
Journal:  Immunol Rev       Date:  2004-12       Impact factor: 12.988

10.  Maximum-likelihood density modification.

Authors:  T C Terwilliger
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2000-08
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  87 in total

Review 1.  Structure and function of interleukin-22 and other members of the interleukin-10 family.

Authors:  Daniela Barretto Barbosa Trivella; José Ribamar Ferreira-Júnior; Laure Dumoutier; Jean-Christophe Renauld; Igor Polikarpov
Journal:  Cell Mol Life Sci       Date:  2010-05-08       Impact factor: 9.261

2.  Type III IFNs in pteropid bats: differential expression patterns provide evidence for distinct roles in antiviral immunity.

Authors:  Peng Zhou; Chris Cowled; Shawn Todd; Gary Crameri; Elena R Virtue; Glenn A Marsh; Reuben Klein; Zhengli Shi; Lin-Fa Wang; Michelle L Baker
Journal:  J Immunol       Date:  2011-01-28       Impact factor: 5.422

3.  IFN-lambda determines the intestinal epithelial antiviral host defense.

Authors:  Johanna Pott; Tanel Mahlakõiv; Markus Mordstein; Claudia U Duerr; Thomas Michiels; Silvia Stockinger; Peter Staeheli; Mathias W Hornef
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-25       Impact factor: 11.205

4.  Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages.

Authors:  Christophe Paget; Stoyan Ivanov; Josette Fontaine; Joelle Renneson; Fany Blanc; Muriel Pichavant; Laure Dumoutier; Bernhard Ryffel; Jean Christophe Renauld; Philippe Gosset; Pierre Gosset; Mustapha Si-Tahar; Christelle Faveeuw; François Trottein
Journal:  J Biol Chem       Date:  2012-01-31       Impact factor: 5.157

Review 5.  Genetics of IL28B and HCV--response to infection and treatment.

Authors:  C Nelson Hayes; Michio Imamura; Hiroshi Aikata; Kazuaki Chayama
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2012-05-29       Impact factor: 46.802

Review 6.  Interferons: Success in anti-viral immunotherapy.

Authors:  Fan-ching Lin; Howard A Young
Journal:  Cytokine Growth Factor Rev       Date:  2014-07-29       Impact factor: 7.638

Review 7.  Investigations of interferon-lambda for the treatment of cancer.

Authors:  Andrew Stiff; William Carson
Journal:  J Innate Immun       Date:  2015-02-06       Impact factor: 7.349

Review 8.  The genetic theory of infectious diseases: a brief history and selected illustrations.

Authors:  Jean-Laurent Casanova; Laurent Abel
Journal:  Annu Rev Genomics Hum Genet       Date:  2013-05-29       Impact factor: 8.929

Review 9.  Genetic variants at the IFNL3 locus and their association with hepatitis C virus infections reveal novel insights into host-virus interactions.

Authors:  Sreedhar Chinnaswamy
Journal:  J Interferon Cytokine Res       Date:  2014-02-20       Impact factor: 2.607

10.  Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1.

Authors:  Zachary J Miknis; Eugenia Magracheva; Wei Li; Alexander Zdanov; Sergei V Kotenko; Alexander Wlodawer
Journal:  J Mol Biol       Date:  2010-10-08       Impact factor: 5.469
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