| Literature DB >> 19457667 |
György Szabó1, Róbert Kiss, Dóra Páyer-Lengyel, Krisztina Vukics, Judit Szikra, Andrea Baki, László Molnár, János Fischer, György M Keseru.
Abstract
Hit-to-lead optimization of a novel series of N-alkyl-N-[2-oxo-2-(4-aryl-4H-pyrrolo[1,2-a]quinoxaline-5-yl)-ethyl]-carboxylic acid amides, derived from a high throughput screening (HTS) hit, are described. Subsequent optimization led to identification of in vitro potent cannabinoid 1 receptor (CB1R) antagonists representing a new class of compounds in this area.Entities:
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Year: 2009 PMID： 19457667 DOI： 10.1016/j.bmcl.2009.05.010
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823