| Literature DB >> 19457609 |
Kanako Yuki1, Atsushi Natsume, Hidenori Yokoyama, Yutaka Kondo, Masasuke Ohno, Takenori Kato, Phassarin Chansakul, Motokazu Ito, Seung-Up Kim, Toshihiko Wakabayashi.
Abstract
The response of cancer patients to interferon (IFN) treatment is long-lasting, indicating that IFN may act on small cancer stem cell populations. Glioma-initiating cells (GICs) can self-renew and induce the formation of heterogeneously differentiated tumor cells and are resistant to chemotherapeutic agents like temozolomide. In this study, we showed that via STAT3 signaling, IFN-beta suppressed the proliferation, self-renewal, and tumorigenesis of GICs, induced their terminal differentiation to mature oligodendroglia-like cells, and exhibited synergistic cytotoxicity with temozolomide. Therefore, IFN may be a potential therapeutic agent for inducing the terminal differentiation of GICs.Entities:
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Year: 2009 PMID： 19457609 DOI： 10.1016/j.canlet.2009.04.020
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679