| Literature DB >> 19457576 |
Andrej Jedinak1, Shailesh Dudhgaonkar, Daniel Sliva.
Abstract
Tumor-associated macrophages were linked to the growth, angiogenesis, and metastasis of variety of cancers. However, the role of macrophages in colon cancer is elusive. In the present study, we demonstrate that activated macrophage-conditioned medium (AMCM), containing tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6, markedly induced proliferation and migration of human colon cancer cells HCT116. Furthermore, AMCM significantly increased activation of transcription factor NF-kappaB and secretion of vascular endothelial growth factor (VEGF) from colon cancer cells, which subsequently induced capillary morphogenesis of human aortic endothelial cells. In conclusion, the interruption of signaling between activated macrophages and colon cancer cells could be considered as a new therapeutic strategy. 2009 Elsevier GmbH. All rights reserved.Entities:
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Year: 2009 PMID： 19457576 DOI： 10.1016/j.imbio.2009.03.004
Source DB: PubMed Journal: Immunobiology ISSN： 0171-2985 Impact factor: 3.144