| Literature DB >> 19457552 |
Carlos M Santamaría1, Maria C Chillón, Ramón García-Sanz, Cristina Pérez, María D Caballero, Fernando Ramos, Alfonso García de Coca, José M Alonso, Pilar Giraldo, Teresa Bernal, José A Queizán, Juan N Rodriguez, Pascual Fernández-Abellán, Abelardo Bárez, María J Peñarrubia, María B Vidriales, Ana Balanzategui, María E Sarasquete, Miguel Alcoceba, Joaquín Díaz-Mediavilla, Jesús F San Miguel, Marcos Gonzalez.
Abstract
The PI3/AKT pathway is up-regulated in acute myeloid leukemia (AML), but its prognostic relevance in cytogenetically normal AML (CN-AML) is unclear. We evaluated RNA levels of AKT and two downstream substrates (FOXO3a-p27) in 110 de novo CN-AML, included in the Spanish PETHEMA therapeutic protocols. Patients with high FOXO3a gene expression displayed shorter OS (p=0.015) and RFS (p=0.048) than low FOXO3a expressers. Features selected in the multivariate analysis as having an independent prognostic value for a shorter survival were WBC>50x10(9)/L, age >65 years and high FOXO3a expression. We concluded that FOXO3a assessment could contribute to improve the molecular-based risk stratification in CN-AML.Entities:
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Year: 2009 PMID： 19457552 DOI： 10.1016/j.leukres.2009.04.024
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156